OXYTOCIN, VASOPRESSIN & SOCIAL BEHAVIOR IN NON HUMAN PRIMATES

最近的几项研究表明，中枢催产素和 加压素通路对于物种典型的社会性 啮齿动物的行为 这项建议将这项工作扩展到非人类 灵长类动物通过调查催产素和加压素在正常和 社交异常的恒河猴。 拟议的研究将描述 这些猴子的社会和认知缺陷， 中枢给药激动剂和拮抗剂的影响，以及 尸检研究，评估催产素和加压素的功能， 细胞和分子技术。 许多行为缺陷 在这些社会异常的猴子中， 自闭症和精神分裂症的缺陷综合征， 提出的研究可能提供病理生理学的见解和新的 治疗这些难治性综合征的药物。 我们有 最近完成了一系列关于恒河猴面部识别的研究 猴子使用丽莎帕尔开发的计算机辅助范例 还有比尔霍普金斯。 我们最近收到通知， 向NIMH申请进一步研究该主题的资金。 这些研究的动物将在今年招募。 资助Yerkes / Venture $20，000 1/01/98 - 12/31/99 Publications无

Several recent studies have demonstrated that central oxytocin and vasopressin pathways are important for species typical social behaviors in rodents. This proposal extends this work to non-human primates by investigating oxytocin and vasopressin in both normal and socially abnormal rhesus monkeys. Proposed studies will characterize the social and cognitive deficits in these monkeys, investigate the influence of centrally administered agonists and antagonists, and in post-mortem studies, assess oxytocin and vasopressin function with cellular and molecular techniques. As many of the behavioral deficits in these socially abnormal monkeys resemble the core features of autism and the deficit syndrome of schizophrenia, the results from the proposed studies may provide pathophysiologic insights and novel medications for these treatment-refractory syndromes. We have recently completed a series of studies of face recognition by rhesus monkeys using the computer assisted paradigm developed with Lisa Parr and Bill Hopkins. We have recently received notice of the successful application for funding for further studies of this topic from NIMH. Animals for these studies will be recruited this year. FUNDING Yerkes / Venture $20,000 1/01/98 - 12/31/99 PUBLICATIONS None