CHIMPANZEE BREEDING & RESEARCH PROGRAM

避孕由于几乎所有的动物都是群居的， 继续在避孕方面投入大量努力， 预防新的怀孕。 继续观察月经 周期性，我们选择宫内节育器作为主要的避孕方法。 到目前为止，通过超过508个繁殖暴露周期，我们观察到， 三次怀孕，只有一次宫内节育器移位的临床问题 从子宫进入膀胱）。 失败率为0.6%， 与人类使用的预测一致。 之预计年期 IUD至少5年。 安置由直接监测 常规临床检查时的可视化、超声或X线检查 调查. 此外，繁殖队列中的几只雌性 植入Norplant，6只雄性动物接受输精管结扎。 到目前为止，已经从124只黑猩猩身上收集了DNA， 纯基因试剂盒。 这是一个持续的过程，包括基因分型， 博士斯通和他在Trinity大学的工作人员根据殖民地的要求 管理 已编写标准操作程序， 为护理人员实施，以协助在主 中心 此外，埃默里大学关于环境富集的政策， 非人类灵长类动物已更新，以反映最近的阐述， 该计划，并已附上广泛的参考书目， 培训目的。 在未来一年，我们打算保持严格的 限制黑猩猩的繁殖，并继续致力于改善 管理我们的黑猩猩群体 这些计划包括使用 积极强化训练与非结构化的人际互动， 为圈养在室内-室外跑道上的黑猩猩提供营养; 记录课程和社会介绍的成功， 引进采用自动点唱机控制的电脑的新项目 视频任务作为丰富。 资助NIH /RR 03591 $417，694 9/01/95 - 2000年8月31日出版物Gould，K.G.使用宫内避孕器作为管理工具， 黑猩猩（Pan troglodytes） J. Med. Primatol. (In Press）。 P51 RR 00165 -38 1998年1月1日至1998年12月31日耶基斯地区灵长类动物研究 中心

Contraception As virtually all of our animals are housed socially, considerable effort has continued to be invested in contraception to prevent new pregnancies. To continue observation of menstrual cyclicity, we have chosen IUDs as the primary method of contraception. Thus far, with over 508 cycles of breeding exposure, we have observed three pregnancies and only one clinical problem migration of an IUD from the uterus into the bladder). This is a 0.6% failure rate, in keeping with that predicted from human use. The expected life of the IUD is at least 5 years. Placement is monitored by direct visualization, ultrasound, or x-ray at time of routine clinical survey. In addition, several females within the breeding cohort have been implanted with Norplant and 6 males have undergone vas ligation. To date, DNA has been collected from 124 chimpanzees using the Puregene kit. This is an ongoing process that includes genotyping by Dr. Stone and his staff at Trinity Univ ersity as required for colony management. Standard Operating Procedures have been written and implemented for carestaff to assist in enrichment duties at the Main Center. In addition, the Emory Policy on Environmental Enrichment for Nonhuman Primates has been updated to reflect recent elaborations to the program, and an extensive bibliography has been attached for training purposes. In the next year, we intend to maintain strict limits on chimpanzee breeding and to continue to focus on improving the management of our chimpanzee colony. These plans include use of positive reinforcement training vs. unstructured human interaction as enrichment for chimpanzees housed in indoor-outdoor runs; documentation of the course and success of social introductions and introduction of new projects involving joystick-controlled computer video tasks as enrichment. FUNDING NIH / RR03591 $417,694 9/01/95 - 8/31/00 PUBLICATIONS Gould, K.G. Use of IUDs as a management tool for the chimpanzee (Pan troglodytes). J. Med. Primatol. (In press). P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center