CHORIOAMNIONITIS: VERTICAL TRANSMISS OF HIV MODEL: THERAP INTERVENT STRATEGIES

这个项目是一个正在进行的调查的延续， 与垂直运动相关的病理生物学和因素 猴/人类免疫缺陷病毒（SIV/HIV）的传播。 在 TRPRC利用猿猴免疫缺陷病毒进行的研究 （SIV）感染的妊娠猕猴、绒毛膜炎（CA）和/或 胎盘组织内炎性浸润增加， 与胎盘组织中SIV抗原增加相关， 胎儿死亡和SIV传播给婴儿。 在第一年 （1998-99），该项目将开发一个灵长类动物模型， 通过引入2种不同的物种和4种剂量的 细菌进入绒毛膜蜕膜间隙。 年间 2-5，CA将在一组SIV感染的猴中诱导， 在这个组中的传输结果将与一组 用SIV单独感染的猴子来直接检验这一假设， 胎盘组织内炎性细胞浸润增加 提高免疫缺陷病毒的传播率， 从母亲到婴儿 定时育种计划于1998年底开始， 怀孕的猴子现在正在接受超声波评估，开始这一过程 项目 SIV补充资金出版物 没有一

This project is a continuation of an ongoing investigation into the pathobiology of and factors associated with the vertical transmission of the Simian/Human Immunodeficiency Virus (SIV/HIV). In studies at TRPRC utilizing simian immunodeficiency virus (SIV)-infected pregnant macaques, chorioamnionitis (CA) and/or increased inflammatory infiltrates within placental tissues was associated with increased SIV antigen within placental tissues, early fetal demise, and SIV transmission to the infant. During year one (1998-99), this project will develop a primate model of chorioamnionitis by introducing 2 different species and 4 doses of bacteria into the choriodecidual space during pregnancy. During years 2-5, CA will be induced in a group of SIV-infected monkeys and the transmission outcome in this group will be compared to a group of monkeys infected with SIV alone to directly test the hypothesis that increases in inflammatory cell infiltrates within placental tissues increase the rate of transmission of immunodeficiency virus from mother to infant. Timed breeding programs were begun late in 1998 and pregnant monkeys are now being evaluated by ultrasound to begin this project. FUNDING Base Grant SIV Supplemental Funding PUBLICATIONS None