TYPE 1 ADENYLYL CYCLASE IN PRIMATE BRAIN

1型腺苷酸环化酶（AC-1）是一种位于大脑中的酶 它被认为在学习中起着重要的作用， 记忆 一项对大鼠的研究表明，AC-1的基因表达 在海马结构的几组神经元中， 大脑的一个亚结构，很明显与老年痴呆症有关 疾病和其他与痴呆相关的神经系统疾病。 在 本研究我们验证了AC-1位于 灵长类动物的海马，特别是在神经通路的 海马体，在那里损伤与长期的 增强作用是一种神经生理学现象， 在神经细胞的水平上调节学习。 研究表明 事实上，AC-1在海马中很容易被证明， 灵长类动物的形成。 此外，它是最突出的， 苔藓纤维通路，海马结构的一个亚结构， 明显与长时程增强有关 资助NIH赠款 LM/OD 06243和RR 00166。

Type-1 adenylyl cyclase (AC-1) is an enzyme located in the brain that has been implicated as playing an important role in learning and memory. A study in the rat showed that the gene for AC-1 is expressed in several groups of neurons in the hippocampal formation, a substructure of the brain that is clearly involved in Alzheimer's disease and other neurological disorders associated with dementia. In this study we tested the hypothesis that AC-1 is located in the hippocampus of primates, and particularly in nerve pathways of the hippocampus, where damage is associated with impairment of long-term potentiation, a neurophysiological phenomenon that is believed to mediate learning at the level of the nerve cell. The study showed that, indeed, AC-1 was readily demonstrated in the hippocampal formation of the primate. Furthermore it was most prominent in the mossy fiber pathway, a substructure of the hippocampal formation most clearly implicated in long-term potentiation. FUNDING NIH grants LM/OD 06243 and RR00166.