VAGINAL MICROBICIDES TO PREVENT VAGINAL SIV TRANSMISSION

448意义艾滋病毒主要是一种性传播疾病 但人们对病毒变异体的传播知之甚少， 性接触 女性控制的方法的开发 预防艾滋病毒的性传播是减少艾滋病毒感染的一个关键需要。 艾滋病对妇女和儿童，特别是发展中国家妇女和儿童 国家 目的本研究利用恒河猴/SIV 测试专利碳水化合物功效的模型 基于角叉菜胶。 卡拉胶是用来做冰淇淋的 光滑。 结果4只成年雌性恒河猴 将1 ml化合物置于阴道中。 等了5分钟后， 将1 ml SIVmac 251置于阴道中。 这份礼物， 重复一次激发程序。 监测动物的 SIV感染4个月。 4只动物中有2只未感染SIV 感染的化合物。 这一积极的结果表明， 安全、无刺激性的化合物将有助于预防艾滋病毒 传输 未来方向合作者试图 产生具有更高功效的化合物。 关键词杀微生物剂，艾滋病毒 人口理事会

448 Significance HIV is primarily a sexually transmitted disease but little is known about the transmission of viral variants during sexual contact. Development of a women-controlled methods for preventing sexual HIV transmission is a critical need for reducing the impact of AIDS on women and children, especially in developing countries. Objectives In this study, we used the rhesus macaque/SIV model to test the efficacy of a proprietary carbohydrate compound based on carrageenans. Carrageenans are used to make ice cream smooth. Results Four mature female rhesus macaques were treated by placing 1 ml of the compound in the vagina. After waiting 5 minutes, 1 ml of SIVmac251 was placed into the vagina. This treat and challenge procedure was repeated once. The animals were monitored for SIV infection for 4 months. Two of 4 animals were protected from SIV infection by the compound. This positive result suggests that very safe, non-irritating compounds will be useful for preventing HIV transmission. Future Directions The collaborator is attempting to produce a compound with higher efficacy. KEY WORDS microbicides, HIV mucosal transmission FUNDING Population Council