ENHANCEMENT OF IMMUNE RESPONSES TO P55

448重要性包括艾滋病毒在内的传染病可导致 死亡 疫苗仍然是预防传染病的最佳方法 疾病 更好地了解增强免疫力的因素 这些反应可能使研制这种疫苗成为可能。 趋化 是调节免疫细胞在组织中运输的分子。 因此，趋化因子在任何免疫应答中具有中心作用。 在这项研究中，我们试图确定趋化因子是否可以 增加对病毒抗原的系统免疫反应。 结果 用SIV抗原p55皮内免疫四只动物。 两只动物在免疫时接受100 μ g MIP。 期间 4个月观察期内， 两组动物中的应答和抗体滴度均为 相似 未来方向研究正在继续， 确定是否有更好的方案来引发免疫反应 使用趋化因子作为佐剂。 关键词免疫应答，佐剂 资助NIH Grant RR00169

448 Significance Infectious diseases, including HIV, can result in death. Vaccines remain the best approach to preventing infectious diseases. A better understanding of the factors which enhance immune responses may make it possible to develop such vaccines. Chemokines are molecules, which regulate the traffic of immune cells in tissues. Thus, chemokines have a central role in any immune response. Objectives In this study, we sought to determine if a chemokine could increase the systemic immune responses to a viral antigen. Results Four animals were immunized intradermally with an SIV antigen, p55. Two animals received 100ug of MIP at the time of immunization. During a 4 month observation period the number of T-cell proliferative responses and the antibody titers in both group of animals were similar. Future Directions Studies are continuing in order to determine if there is a better protocol for eliciting immune responses using chemokines as adjuvants. KEY WORDS immune responses, adjuvants FUNDING NIH Grant RR00169