MANGANESE & INFANT FORMULA ON MANGANESE & IRON STATUS OF INFANTS

婴儿配方奶粉中锰的含量比母乳高得多。由于锰的身体负荷非常高可能会产生毒性作用，因此研究从各种类型的配方奶粉中吸收锰的程度以及婴儿锰的状况如何受到影响是很重要的。此外，由于锰和铁在吸收方面存在竞争，因此评估高锰摄入对血液学和铁状态的影响非常重要。目的研究不同锰含量（35 ~ 200 ug/L）的乳基和豆基婴儿配方奶粉对出生~ 6月龄幼猴生长、锰吸收和状态的影响，以及对血液、铁吸收和状态的影响。结果6周龄时，锰含量最高配方（大豆配方）对锰和铁的吸收率显著低于其他配方。然而，在3个月大时，各组之间没有差异，这表明身体锰负荷不影响锰潴留。全血锰反映了锰的摄入量，以锰水平最高的配方饲料组最高，血清铁蛋白水平较低。未来的发展方向：评估锰在体内水平的增加对各种生理功能的影响。关键词锰，锰吸收，铁，铁状态，婴儿营养

Significance Infant formulas contain considerable higher concentrations of manganese than human milk. Since very high body burdens of manganese may have toxic effects, it is important to study how well manganese is absorbed from various types of formula and how manganese status of infants is affected. Further, as manganese and iron compete for absorption, it is important to assess the effect of high manganese intake on hematology and iron status. Objectives To feed milk-based and soy-based infant formulas with different levels of manganese (35-200 ug/L) to infant monkeys from birth to 6 months of age and to study the effects on growth, manganese absorption and status, and the effects on hematology, iron absorption and status. Results Manganese and iron absorption was significantly lower from the formula with the highest level of manganese (soy formula) than from all other formulas at 6 weeks of age. At 3 months of age, however, there was no difference between the groups, suggesting that body burden of manganese does not affect manganese retention. Whole blood manganese reflected manganese intake and was highest in the group fed formula with the highest manganese level, while serum ferritin was lower in this group. Future Directions To evaluate the effect of increased levels of manganese in the body on various physiological functions. KEYWORDS manganese, manganese absorption, iron, iron status, infant nutrition