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GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS

GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS
NIDDM 与动脉粥样硬化之间的遗传关系
批准号：
6117155
负责人：
LESLIE RAFFEL
金额：
$3.89万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6117155
关键词：
Hispanic Americans atherosclerosis clinical research coronary artery coronary disorder disease /disorder proneness /risk family genetics genetic disorder human genetic material tag human subject noninsulin dependent diabetes mellitus tissue /cell culture

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中文摘要
翻译
尽管患有非胰岛素依赖型糖尿病(NIDDM)的人 有明显更高的冠状动脉疾病和NIDDM风险 在拉美裔美国人中，这种情况发生的频率越来越高 在这一组中动脉粥样硬化的发病率比非西班牙裔要少得多 高加索糖尿病患者。这一观察结果的遗传学基础 正在西班牙裔NIDDM患者的家庭中进行测试 没有冠状动脉疾病。淋巴母细胞系的建立是为了 组织培养设施中的DNA研究。
英文摘要
Although individuals with noninsulin dependent diabetes mellitus (NIDDM) have a significantly higher risk for coronary artery disease and NIDDM occurs with increased frequency in Hispanic Americans, the occurrence of atherosclerosis is much less in this group than in non Hispanic Caucasian diabetic individuals. The genetic basis for this observation is being tested in the families of Hispanic NIDDM patients with and without coronary disease. Lymphoblastoid cell lines are established for DNA studies in the Tissue Culture Facility.
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会议论文
GENNID--NIDDM FAMILY ACQUISITION CENTER
GENETIC RELATIONSHIPS BETWEEN NIDDM AND ATHEROSCLEROSIS
MOLECULAR GENETICS OF HYPERTENSION
DIABETES PREVENTION TRIAL-TYPE 1 DIABETES (DPT-1)
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