ELLAGITANNINS & CANCER PREVENTION

鞣花酸是鞣皮单宁家族的一种酚类化合物，天然存在于覆盆子、草莓和核桃中，含量很高。在过去的20年里，鞣花酸和其他鞣皮单宁在动物和细胞模型中被证明是有效的化学预防药物。这项研究的长期目标和目的是确定食物来源中的鞣质是否可以预防人类癌症。在此之前，必须评估来自食品来源的鞣花酸和鞣花单宁的药代动力学特性。在目前的研究中，志愿者(12人)将食用含有类似数量的鞣质单宁的树莓、草莓和核桃样本。通过比较血清和尿液中的鞣皮单宁水平，可以看出哪种食物提供的这些化合物的浓度最高，最适合在人类化学预防临床试验中进行进一步研究。

Ellagic acid, a phenolic compound from the family of Ellagitannins, is naturally found in high concentrations in raspberries, strawberries, and walnuts. For the last 20 years ellagic acid and other ellagitannins have been shown to be effective chemopreventive agents in animal and cell models. The long term goal and objective of this study is to determine if the ellagitannins present in food sources can prevent cancer in humans. Before this can be done, the pharmacokinetic properties of the ellagic acid and the ellagitannins from food sources must be assessd. In the current study volunteers (12) will consume samples of raspberries, strawberries, and walnuts containing similar amounts of ellagitannins. Comparison of the serum and urine levels of ellagitannins will show which food provides the highest concentration of these compounds and is most suited for further study in human chemoprevention clinical trials.