OBESE HYPERTENSIVE PATIENTS

确定奥利司他加低热量饮食对未充分控制降压药的肥胖高血压患者52周体重变化的影响。确定奥利司他加低张饮食对52周内未充分控制降压药物的肥胖高血压患者坐位舒张压控制的影响。次要目的：确定与安慰剂加低热量饮食相比，奥利司他加低热量饮食治疗的患者舒张压<9.0 mmHg或坐位舒张压较基线降低大于10 mmHg的百分比。确定与安慰剂加低热量饮食相比，奥利司他加低热量饮食治疗的患者体重从基线降低至少5%的百分比。确定奥利司他加低热量饮食对未充分控制降压药物的肥胖高血压患者坐位收缩压控制的影响。确定奥利司他加低热量饮食对空腹脂质谱（总胆固醇、HDL、LDL、LDL/HDL比值和甘油三酯）和腰围的影响。评估奥利司他在该人群中的安全性。

To determine the effect of orlistat plus a hypocaloric diet on change in body weight over 52 weeks in obese hypertensive patients inadequately controlled with antihypertensive medication(s). To determine the effect of orlistat plus a hypoclaroic diet on sitting diastolic blood pressure control over 52 weeks in obese hypertensive patients inadequately controlled with antihypertensive medication(s).Secondary objectives: To determine the percentage of patients treated with orlistat plus a hypocaloric diet compared to placebo plus hypocaloric diet achieve a diastolic blood pressure <9.0 mmHg or a decrease in sitting diastolic blood pressure of greater than 10 mmHg from baseline. To determine the percentage of patients treated with orlistat plus a hypocaloric diet compared to placebo plus hypocaloric diet achieving at least 5% reduction in body weight from baseline. To determine the effect of orlistat plus a hypocaloric diet on sitting systolic blood pressure control in obese hypertensive patients inadequately controlled with antihypertensive medication(s). To determine the effect of orlistat plus a hypocaloric diet on fasting lipid profile (total cholesterol, HDL, LDL, LDL/HDL ratio and triglycerides) and waist circumference. To assess the safety of orlistat in this population.