INSULIN SECRETION CAPACITY & INSULIN RESISTANCE IN SUBJECTS W/ VARIANT GENE

胰腺β细胞上表达的高亲和力磺酰脲受体（SUR1）是葡萄糖刺激胰岛素分泌的关键组分。研究人员先前报道了墨西哥裔美国人2小时血糖水平与SUR1基因附近区域的联系，并观察到该基因外显子31中的沉默变异体，该变异体与墨西哥裔美国人2型糖尿病家族的非糖尿病成员的高胰岛素浓度相关。 尚不清楚这是由于原发性胰岛素分泌过多还是胰岛素抵抗的代偿性胰岛素反应。 这项研究将比较15名非糖尿病墨西哥裔美国人的胰岛素分泌和胰岛素抵抗，这些人是SUR1基因变异体的纯合子，15名受试者是野生型等位基因的纯合子，并且是先前圣安东尼奥家族糖尿病研究的基因分型参与者。

The high-affinity sulfonylurea receptor (SUR1) expressed on the beta cells of the pancreas is a key component in glucose-stimulated insulin secretion. The investigators have previously reported linkage of 2-hour plasma glucose levels to a region near the SUR1 gene in Mexican Americans and observed a silent variant in exon 31 of the gene which was associated with high insulin concentrations in non-diabetic members of Mexican American type 2 diabetic families. It is not known whether this is due to primary oversecretion of insulin or compensatory insulin response to insulin resistance. This study will compare insulin secretion and insulin resistance in 15 non-diabetic Mexican Americans homozygous for this variant of the SUR1 gene and 15 subjects who are homozygous for the wildtype allele and who were previously genotyped participants of the San Antonio Family Diabetes Study.