CORE--SOLID TUMOR PHARMACOLOGY

实体肿瘤药理学核心的职能是： A.进行分析以量化药物和药物代谢物 从动物和动物采集的生物标本中的浓度 患者作为临床前和临床药代动力学研究的一部分 在本计划内。 B.根据需要执行额外的特殊实验室程序，以 支持本计划中包含的项目。 C.进行适当的生化分析(例如，免疫印迹分析 对于拓扑异构酶I，拓扑异构酶I的催化活性 用于评价抗癌活性的临床前和临床样本 为药物提供更全面的药效学分析。 D.维护数据的计算机数据库，这些数据来自 实体肿瘤药理学核心，并生成数据检索和报告 视需要而定。 E.分析从临床前和临床获得的药代动力学数据 药代动力学研究，并符合适当的药代动力学和 数据的药效学模型，应研究人员的要求 这个节目。

The functions of the Solid Tumor Pharmacology Core are to: A. Perform assays to quantitate drug and drug metabolite concentrations in biological specimens collected from animals and patients as part of preclinical and clinical pharmacokinetic studies within this Program. B. Perform additional special laboratory procedures as required to support the projects included in this Program. C. Perform appropriate biochemical assays (e.g., immunoblot analysis for topoisomerase I, catalytic activity of topoisomerase I) on preclinical and clinical samples to evaluate the activity of anticancer drugs to provide more comprehensive pharmacodynamic analyses. D. Maintain computer databases of data from analyses performed in the Solid Tumor Pharmacology Core, and generate data retrievals and reports as required. E. Analyze pharmacokinetic data obtained from preclinical and clinical pharmacokinetic studies, and fit appropriate pharmacokinetic and pharmacodynamic models to the data, as requested by investigators in this Program.