ACQUISITION OF 500 MHZ NMR SPECTROMETER

这项提案要求为垂直井筒提供部分资金， 用于高分辨率光谱研究的野外核磁共振谱仪 结构生物学。该乐器将由一辆11.75特斯拉组成 磁体，足够均匀的体积，可容纳8 mm的样品管， 和光谱仪硬件，具有先进的 梯度增强光谱、三重共振等技术 实验、过采样能力、数字滤波等 现代多维核磁共振方法所需的其他功能。 光谱仪将由五个主要用户组成的核心小组使用 (全部由核磁共振研究的外部资金提供)和几个辅修项目 用户。主要用户的项目主要集中在核磁共振应用到 结构生物学。使用拟议的光谱仪计划进行的研究 重点研究生物分子结构。调查人员已经 建立了利用LESER光谱仪进行核磁共振研究的程序 能力，并且建议书记录了要满足以下条件的附加知识 通过拟议文书的新能力而获得的。 拟议的文书将由加州大学戴维斯分校赞助 核磁共振设备。该设施有超过17年的证明记录在 实施最先进的核磁共振技术，并在光谱仪中 维护和修改。

This Proposal requests partial funding for a vertical bore, high field NMR spectrometer for high resolution spectroscopic studies in structural biology. The instrument will consist of a 11.75 Tesla magnet, sufficient homogeneous volume for up to 8 mm sample tubes, and spectrometer hardware with all features necessary for advanced techniques such as gradient enhanced spectroscopy, triple resonance experiments, oversampling capability, digital filtering, and all other features necessary for modern multidimensional NMR methods. The spectrometer will be utilized by a core group of five Major Users (all with extramural funding for NMR research) and several minor users. The projects of the Major Users focus on NMR applications to structural biology. Planned research using the proposed spectrometer emphasizes studies of biomolecule structure. The investigators have established programs of NMR research with spectrometers of lesser capability, and the Proposal documents the additional knowledge to be gained by the new capabilities of the proposed instrument. The proposed instrument will come under the auspices of the UC Davis NMR Facility. The Facility has a proven record of over 17 years in implementing state-of-the-art NMR techniques, and in spectrometer maintenance and modification.