THERMODYNAMIC STABILITY OF SEMIQUINONES AS A FUNCTION OF THEIR ENVIRONMENT

半喹酮是一种重要的中间体，被认为参与了 含醌类药物的细胞毒活性。这些药物的功效 活动应取决于体系的热力学稳定性 半喹酮类。这种稳定性取决于 半喹酮类和对半喹酮类环境的侵犯。它是 本子项目的目的是确定热力学参数 控制半喹诺酮类药物的内部稳定性以及 半喹酮-环境相互作用。 一旦知道了这些热力学参数，它们对 半喹酮与氧的氧化还原反应，包括脂质过氧化， 将会被确定。学生们将在这个子项目中接受全面的培训 生物医学研究过程的各个方面，目的是 将他们提升到生物医学研究职业。

Semiquinones are important intermediates postulated to be involved in the cytotoxic activities of quinone-containing drugs. The efficacy of these activities should depend on the thermodynamic stability of the semiquinones. This stability depends on the internal structure of the semiquinones and on the semiquinone-environment infractions. It is the purpose of this subproject to determine the thermodynamic parameters controlling the internal stability of semiquinones as well as semiquinone-environment interactions. Once these thermodynamic parameters are known, their effect on semiquinone redox reactions with oxygen, including lipid peroxidation, will be determined. Students will be trained in this subproject in all the aspects of the biomedical research process with the purpose of promoting them to biomedical research careers.