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REGULATION OF GENE EXPRESSION BY GROWTH HORMONE AND RELATED GROWTH FACTORS

REGULATION OF GENE EXPRESSION BY GROWTH HORMONE AND RELATED GROWTH FACTORS
生长激素和相关生长因子对基因表达的调节
批准号:
6244557
负责人:
Jessica Schwartz
金额:
$2.22万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-02-20 至 1997-11-30

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项目成果

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中文摘要
翻译
生长激素对基因表达的调控是研究生长激素对基因表达调控的一个热点。 GH的作用机制 在3 T3-F442 A细胞中,GH诱导c-fos 通过血清反应元件(SRE)转录。 我们 研究转录因子的参与, SRE和SIF结合序列在GH的作用。 其他方法 包括研究GH受体和c-fos酪氨酸之间信号传导 激酶,并评估表达反义c- fos.
英文摘要
Regulation of gene expression by GH is a focus to understand the mechanism of action of GH. In 3T3-F442A cells, GH induces c-fos transcription, via the serum response element (SRE). We are investigating involvement of transcription factors associated with the SRE and with the SIF-binding sequence in GH action. Other approaches include studying signaling between GH receptors and c-fos tyrosine kinase, and assessment of GH action in cells expressing anti-sense c- fos.
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会议论文
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