FACTORS IN ANGIOGENESIS OF KAPOSI'S SARCOMA CELLS

卡波济氏肉瘤（KS）是最常见和致命的后遗症之一， 获得性免疫缺陷综合症（艾滋病）。散射因子（SF），a 间充质细胞衍生的细胞因子，也称为肝细胞生长 因子，是HIV感染的条件性T淋巴细胞的主要成分 培养基（HTLV-II CM）。 我们假设，SF发挥了核心作用， 艾滋病相关KS的病因和发病机制：1）诱导 由艾滋病“引发”的EC表型转化 相关感染因子，即HHV 8病毒，2）通过促进 表型转化/启动EC的克隆扩增和3） 通过刺激肿瘤细胞维持已建立的KS的生长 增殖和新血管形成。

Kaposi's sarcoma (KS) is one of the most common and lethal sequela of acquired immunodeficiency syndrome (AIDS). Scatter factor (SF), a mesenchymal cell-derived cytokine, also known as hepatocyte growth factor, is a major constituent of HIV infected T lymphocyte conditioned media (HTLV-II CM). We hypothesize that SF plays a central role in the etiology and pathogenesis of AIDS associated KS by 1) inducing phenotypic conversion of EC that have been "initiated" by AIDS associated infectious agents, i.e. the HHV8 virus, 2) by promoting the clonal expansion of phenotypically converted/initiated EC and 3) sustaining the growth of established KS by stimulating tumor cell proliferation and neovascularization.