OPIOID INDUCED ALTERATIONS OF IMMUNE STATUS

这些目标将在以下三个框架内实现： 现有的NIH资助项目。 第一个项目，题为行为 阿片类药物/免疫相互作用的决定因素，提供了一个检查 阿片类药物诱导的免疫状态改变，重点是 中枢神经系统和药理学变量在 这些互动。 具体而言，建议是就以下方面进行研究： 急性和慢性阿片类药物给药对免疫功能的影响 功能，并确定参与这些功能的特定大脑区域。 方面的影响. 第二个项目题为免疫改变介导的 条件反射，检查条件反射过程如何调节 免疫状态 这一建议涉及审查以下方面的作用： 内源性阿片类物质在免疫功能的条件调节中的作用。 第三个项目题为“类阿片诱导的一氧化氮改变”， 由外周巨噬细胞产生。 该项目将决定 阿片样物质诱导的阿片样物质受体亚型 一氧化氮产生的改变，并表征 阿片类药物给药对体内一氧化氮产生的影响。 总的来说， 这些项目将提供关于阿片类药物的重要新信息- 诱导免疫系统的调节，这个奖项将 加强这些调查。

These goals will be accomplished within the framework of three existing NIH funded projects. The first project, entitled Behavioral Determinants of Opioid/Immune Interactions, provides an examination of Opioid-induced alterations of immune status with emphasis on the role of the central nervous system and pharmacological variables in these interactions. Specifically, the proposal is to conduct studies on the effects of acute and chronic Opioid administration on immune function, and identify the specific brain regions involved in those effects. The second project entitled Immune Alterations Mediated by conditioning, examines how conditioning processes can modulate immune status. This proposal involves examining the role of endogenous opiates in conditioned modulation of immune function. The third project, entitled Opioid-induced alterations of nitric oxide production by peripheral macrophages. This project will determine the subtype(s) of Opioid receptors involved in Opioid-induced alterations of nitric oxide production, and characterize the effect of Opioid administration on nitric oxide production in vivo. Collectively, these projects will provide important new information about Opioid- induced modulation of the immune system, and this award will enhance these investigations.