DEVELOPMENTAL TOXICITY

描述：初步研究表明，2，2，4，4，5，5-六氯苯 显著抑制3，3，4，4，5-pentaCB介导的致畸性， 未来的合作研究将进一步表征的性质， 这些非加性的相互作用。的发育毒性 氯化苯酚，这是木材防腐的主要成分， 采用一系列发育毒性试验， 试验，包括大鼠体内阶段II研究、Hydra试验、HEPM， 全胚胎培养。这些化合物在原发性 细胞培养生物测定将在今后的研究中进行。外地- 实用的检测方法（微柱测定法）和 已经开发了真菌毒素的解毒（粘土矿物）， 由菲利普斯博士申请专利。基本技术已获得许可， 商业产品目前在世界范围内使用。拟议 该项目的研究将进一步加强这一诊断 检测氯酚（CP），并利用粘土技术 氯化石蜡和其他卤代芳烃的降解 （HAH）与油性和木材防腐废物有关。

Description: Preliminary studies indicated that 2,2,4,4,5,5- HCB significantly inhibited 3,3,4,4,5-pentaCB-mediated teratogenicity and future collaborative studies will further characterize the nature of these non-additive interactions. The developmental toxicity of chlorinated phenols, which are major components of wood-preserving wastes, was investigated using a series of developmental toxicity assays, including in vivo segment II studies in rats, hydra assay, HEPM, and whole embryo culture. The effects of these compounds in primary cell culture bioassays will be carried out in future studies. Field- practical methods for the detection (minicolumn assays) and detoxification (clay minerals) of mycotoxins have been developed and patented by Dr. Phillips. The basic technologies have been licensed and commercial products are currently being used worldwide. The proposed research in this program project will further enhance this diagnostic assay for chlorophenols (CPs) and also utilize clay-based technology for the degradation of CPs and other halogenated aromatic hydrocarbons (HAHs) associated with oily and wood-preserving wastes.