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MEASUREMENT OF AIRWAY TRANSEPITHELIAL POTENTIAL DIFFERENCE IN CYSTIC FIBROSIS

MEASUREMENT OF AIRWAY TRANSEPITHELIAL POTENTIAL DIFFERENCE IN CYSTIC FIBROSIS
囊性纤维化气道上皮电位差的测量
批准号：
6217984
负责人：
Michael R Knowles
金额：
$0.02万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6217984
关键词：
acid base balance amiloride clinical research cystic fibrosis electrodes electrolytes human subject human therapy evaluation inhalation drug administration respiratory disorder chemotherapy respiratory epithelium respiratory therapy secretion sodium

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中文摘要
翻译
本研究旨在检测囊性纤维化患者、疾病对照患者和正常人呼吸道分泌物的组成和呼吸道上皮细胞的生物电学特性。通过测量雾化吸入阿米洛利前后呼吸道表面液体的体积、电解质组成和pH值来确定呼吸道分泌物的组成。使用钠选择电极的研究最近被添加到这项研究中。
英文摘要
This study is designed to examine the composition of airway secretions and the bioelectric properties of respiratory epithelium in cystic fibrosis patients, disease control patients and normal subjects. The composition of airway secretions is determined by measuring the volume, electrolyte composition and pH of airway surface liquid before and after aerosol amiloride administration. Studies using a sodium selective electrode were recently added to this study.
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会议论文
Molecular Phenotypes for Cystic Fibrosis Lung Disease
RARE GENETIC DISORDERS OF THE AIRWAYS
GENETIC DISORDERS OF MUCOCILIARY CLEARANCE: RARE DISEASES: PCD, CF, & PHA
Molecular Phenotypes for Cystic Fibrosis Lung Disease
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