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STEROIDOGENESIS IN HYPERANDROGENISM

STEROIDOGENESIS IN HYPERANDROGENISM
雄激素过多症中的类固醇生成
批准号：
6115516
负责人：
SELMA FELDMAN WITCHEL
金额：
$2.06万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6115516
关键词：
adrenal disorder adrenal glands adrenocorticotropic hormone androgens chorionic gonadotropin clinical research female gene mutation genotype human subject molecular genetics ovary ovary disorder phenotype steroid biosynthesis steroid hormone metabolism

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中文摘要
翻译
这项建议的目标是确定与多囊卵巢综合征(PCOS)的发展相关的激素和遗传因素。多囊卵巢综合征的典型特征在青春期周围变得明显。这项研究有三个主要目标。第一个是确定耻骨早熟的自然病史。二是探讨多囊卵巢综合征中黄体生成素/卵泡刺激素比值升高的个体发生机制。第三个是确定与多囊卵巢综合征发病风险增加相关的遗传标记。
英文摘要
The goals of this proposal are to identify hormonal and genetic factors which are associated with the development of polycystic ovary syndrome (PCOS). The typical features of PCOS become conspicuous during the peri-pubertal period. There are three major goals of this study. The first is to determine the natural history of premature pubarche. The second is to determine the ontogeny of the increased LH/FSH ratio in PCOS. And, the third is to identify genetic markers associated with an increased risk to develop PCOS.
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会议论文
STUDIES OF ABNORMAL SEXUAL DIFFERENTIATION AND DEVELOPMENT:SERUM INHIBIN B & FSH
STEROIDOGENESIS IN HYPERANDROGENISM
EVALUATION & TREATMENT OF ABNORMALITIES OF GONADAL OR PUBERTAL DEVELOPMENT
MOLECULAR DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA: PHENOTYPE/GENOTYPE
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