MENOPAUSE TRANSITION IN BLACK AND WHITE WOMEN--BONE DENSITY DIFFERENCE

探讨黑人和白人妇女更年期过渡对各种生理参数的影响。研究的核心参数包括更年期的流行病学（如绝经年龄和围绝经期长度）、症状学（潮热、情绪等）、社会心理和行为问题、更年期期间性行为的变化，以及更年期对医疗保健利用和健康相关行为的影响。需要研究的具体问题包括：1)绝经对皮质骨密度和骨小梁骨密度的影响；2)绝经对动脉壁厚度及顺应性的影响；3)维生素D受体（VDR）基因型等位基因变异与基线骨密度和骨质流失率的关系；4)利用缪勒管抑制物质（MIS）作为卵巢衰老新标志物的应用；5)使用雌激素活性的放射受体分析来帮助评估更年期症状的差异。除了评估绝经期过渡对这些参数的影响在整个群体中，黑人和白人妇女之间的参数。协议已停止注册。本研究是一项全国性多中心研究的一部分，目前数据分析尚未完成。

To investigate the effects of the menopause transition on a variety of physiological parameters in black and white women. Core parameters to be investigated include the epidemiology of the menopause (e.g. age of menopause and length of perimenopause), symptomatology (hot flashes, mood, etc.) psychosocial and behavioral issues, changes in sexual behavior across the menopause, and the effects of the menopause on health care utilization and health-related behaviors. Specific questions to be investigated include 1) the effects of the menopause on cortical and trabecular bone density; 2) the effects of the menopause on arterial wall thickness and compliance; 3) the relationship of allelic variation in the vitamin D receptor (VDR) genotype to baseline bone density and rates of bone loss; 4) the utility of utilizing Mullerian Inhibiting Substance (MIS) as a new marker of ovarian aging; and 5) use radioreceptor analyses of estrogenic activity to help assess differences in menopausal symptoms. In addition to assessing the impact of the menopause transition on these parameters in the group as a whole, a parameters between black and white women. Protocol is closed for enrollment. This study is part of a nation wide multicenter study and data analysis is not complete at this time.