CENTER FOR STRUCTURAL AND FUNCTIONAL NEUROSCIENCE

该项目的长期目标是建立一个卓越的生物医学研究中心，主要有两个功能：i）促进我们对结构和功能神经科学的理解，ii）增加蒙大拿州NIH-RO 1资助的研究人员的数量。我们建议在蒙大拿大学建立一个结构和功能神经科学中心，使用新教师招聘，所需仪器的开发和子项目支持的良好平衡组合，为有才华的年轻教师已经到位。该中心的研究重点将是与信号转导、发育和神经变性相关的中枢神经系统蛋白质结构和功能。这一主题重点，不仅建立在现有的师资力量，而且还代表了一个领域，在一个不断发展的大学（没有医学院）的跨学科研究可以为我们国家面临的最优先的医疗保健问题之一做出重大贡献：了解和减轻神经系统疾病的负担。拟议的中心将开发使用以下具体目标：目标一-通过战略招聘三个新的教师，提高竞争力的神经科学家在蒙大拿大学的临界质量。目标II -通过支持各个子项目促进有竞争力的神经科学教师的发展目标III -通过为CNS蛋白质结构和功能研究的共享核心光谱实验室购买急需的仪器来加强神经科学研究的基础设施。目标四：为中心神经科学家建立一个支持网络，促进基础设施的发展，协作互动，最重要的是，指导。

The long range goal of this project is to establish a Center of Biomedical Research Excellence that serves two primary function: i) to advance our understanding of Structural and Functional Neuroscience and ii) to increase the number of NIH-RO1-funded investigators in Montana. We propose to create a Center for Structural and Functional Neuroscience at the University of Montana using a well balanced combination of new faculty recruitment, development of needed instrumentation, and sub- project support for talented young faculty already in place. Research in the proposed Center will emphasize CNS protein structure and function as related to signal transduction, development and neurodegeneration. This thematic focus, not only builds on existing faculty strengths, but also represents a field in which interdisciplinary research at a growing University (without a medical school) can make a significant contribution to one of the highest priority health care issues facing our nation: understanding and lessening the burden of neurological diseases. The proposed Center will be developed using the following specific aims: Aim I - Enhance the critical mas of competitive neuroscientists at the University of Montana through strategic recruitment of three new faculty. Aim II - Promote the development of competitive neuroscience faculty through the support of individual subprojects Aim III - Enhance the infrastructure for neuroscience research through the acquisition of critically needed instrumentation for a shared core spectroscopy lab for studies of CNS protein structure and function. Aim IV - Establish a support network for Center neuroscientists that promotes infrastructure development, collaborative interaction and, most importantly, mentoring.