CORE--CENTRAL VIRUS CULTURE

UAB CFAR自2009年以来一直在运行中央病毒核心（CVC）共享资源。 1988.该核心的具体目标是：（1）特别提供- 设计和位于中心的BSL 2-3实验室空间，所有UAB 研究人员，使传染性艾滋病毒的研究， （2）提供和维护高成本设备 在核心设施内进行艾滋病毒基础研究所需的资金， 促进和扩大所有研究人员的研究能力， 避免重复购买设备;（3）提供持续的 培训、监督和监测研究者及其研究 关于与中心进行艾滋病毒研究所需的BSL 2-3实践的工作人员; (4)通过新的和建立的艾滋病毒/艾滋病研究， 调查人员提供了一个CVC工作人员与广泛的经验， 致力于这些目标的临床艾滋病毒研究。CVC由 两个位于中心的生物安全2-3级（BSL 2-3）实验室， 其相关专业和技术人员。这些实验室 位于UAB校园的中心，靠近世界上最大的 艾滋病研究人员的聚集地。它们共同构成了2500平方 英尺的BSL 2-3实验室空间，包括9个独立的100平方米 足部组织培养套件。无论是个人文化套房和 外部公共设备区完全配备了分子， 生物学和临床HIV研究。核心是在 核心咨询委员会确定的具体用途和优先准则 符合NIH/CDC的安全操作建议 程序.自1988年资助以来，45名校长的研究 拥有联邦资助赠款的调查人员已被安置在这些 设施目前，CVC支持24 UAB教师的研究 代表11个不同的部门和部门在学校的 药CVC已经培训、监督和协助了105名研究人员 包括研究生、博士后研究员、技术人员， 教师。目前，共有64个活跃的CVC用户。此外 对于R 01型项目，CVC支持主要NIH的研究 自2009年以来，资助的项目和合同授予UAB调查人员， 1988年，包括NCDDG、NCVDG、PEBRA、ACTG、AVEU、NICHD和HIV遗传学 变异项目。超过300篇同行评审的科学出版物 自1993年以来在CVC内进行的工作的结果。资金 要求支持CVC的基本基础设施费用， 尽管有大量的退款系统。

The UAB CFAR has operated a Central Virus Core (CVC) shared resource since 1988. The specific aims of this core are: (1) To provide specially- designed and centrally-located BSL 2-3 laboratory space to all UAB investigators so that infectious HIV research can by physically restricted to specified areas; (2) To provide and maintain the high cost equipment needed for basic HIV research within the core facility in order to facilitate and broaden the research capabilities of all investigators and to avoid redundancy in equipment purchases; (3) To provide ongoing training, supervision, and monitoring of investigators and their research staff regarding BSL 2-3 practices required for HIV research with the CVC; (4) To foster the development of HIV/AIDS research by new and established investigators by providing a CVC staff with broad experience in basic and clinical HIV research which is dedicated to these goals. The CVC consists of two centrally-located biosafety level 2-3 (BSL 2-3) laboratories and their associated professional and technical staff. These laboratories are centrally located on the UAB campus in the vicinity of the greatest concentrations of HIV researchers. Together, they constitute 2500 square feet of BSL 2-3 laboratory space including nine self-contained 100 square foot tissue culture suites. Both the individual culture suites and the outer common equipment areas are completely equipped for molecular, biological, and clinical HIV research. The core is operated under the specific usages and priority guidelines established by the Core's Advisory Committee and complies with NIH/CDC recommendations for safe operating procedures. Since funded in 1988, the research of 45 principal investigators with federally funded grants have been accommodated in these facilities. Currently, the CVC supports the research of 24 UAB faculty representing 11 different departments and divisions within the School of Medicine. The CVC has trained, supervised, and assisted 105 researchers including graduated students, postdoctoral fellows, technicians, and faculty. Currently, there are a total of 64 active CVC users. In addition to R01-type projects, the CVC has supporter the research of major NIH funded program projects and contracts awarded to UAB investigators since 1988, including NCDDG, NCVDG, PEBRA, ACTG, AVEU, NICHD and HIV Genetic Variation projects. Over 300 peer-reviewed scientific publications have results from work performed within the CVC since 1993. Funding is requested to support the basic infrastructure costs of the CVC that remain despite a substantial chargeback system.