PATHOGENESIS AND THERAPY OF TROPICAL DISEASES

该计划的主要目标是执行流行病学、临床 和免疫学研究，以扩大我们对发病机制的了解， 血吸虫病、利什曼病和持久性疾病的治疗和控制 腹泻病。UFBA/UFC/UFRN/Fiocruz热带医学研究 中心联盟将汇集来自以下国家的调查人员的专业知识 巴西东北部。TMRC将加强我们与 美国科学家将为美国提供机会 调查人员对热带病进行研究。重大疾病 在贫穷的巴西东北部流行的疾病包括： 利什曼病、血吸虫病、丝虫病、恰加斯病、麻风病、 疟疾、肠道感染引起的腹泻和蠕虫病。 总体规划主题是细胞因子在发病机制中的作用 和疾病表现以及治疗和控制的新方法 血吸虫病、利什曼病和持续性腹泻。项目一。 “曼氏沙门氏菌：肝脾功能、人类白细胞抗原和T细胞反应”将决定 人类白细胞抗原II类等位基因对细胞免疫发育的影响 对血吸虫粗抗原和已定义抗原的反应导致了 重症肝脾血吸虫病的发生。项目II。 年内脏利什曼病的自然病史和人类免疫遗传学 巴西的Ceara和Rio Grande do Norte将以免疫学和 与抗病或易感有关的遗传因素 内脏利什曼病的发展。项目III。“中国的免疫调节 利什曼病将决定早期发生的免疫学事件 利什曼病与巨噬细胞的接触及细胞因子(GM-CSF)的作用 和IL-12)作为疫苗佐剂及其免疫学和临床应用 白介素12治疗皮肤利什曼病疗效观察 与五价锑结合。项目IV。“细胞因子的作用， 细胞免疫学决定因素与治疗新途径 隐孢子虫高危人群持续性腹泻， 肠聚集性大肠埃希菌和其他肠道感染“将定义 肠道细胞因子与细胞免疫在生理学中的作用 持续性隐孢子虫、大肠杆菌和其他腹泻的紊乱 并检查新的、基于功能的方法来解决其 心理治疗。

The main objective of this program is to perform epidemiological, clinical and immunological studies to expand our knowledge of the pathogenesis, treatment and control of schistosomiasis, leishmaniasis and persistent diarrheal disease. The UFBA/UFC/UFRN/FIOCRUZ TROPICAL MEDICINE RESEARCH CENTER Consortium will bring together the expertise of investigators from the Northeast of Brazil. The TMRC will increase our collaboration with American scientists and will provide opportunities for United States investigators to conduct research on tropical disease. Major diseases which are endemic in the impoverished Northeast of Brazil include: leishmaniasis, schistosomiasis, filariasis, Chagas' disease, leprosy, malaria, diarrhea due to enteric infections and helminthiasis. The overall programmatic theme is the role of cytokines in pathogenesis and disease expression and novel approaches to treatment and control of schistosomiasis, leishmaniasis and persistent diarrhea. Project I. "S.mansoni: Hepatosplenism, HLA and T cell responses" will determine the influence of HLA class II alleles on the development of cellular immune responses to crude and defined schistosoma antigens that led to the development of severe hepatosplenism schistosomiasis. Project II. "Natural history and human immunogenetics of visceral leishmaniasis in Ceara and Rio Grande do Norte, Brazil" will characterize immunological and genetic factors associated with resistance or susceptibility to the development of visceral leishmaniasis. Project III. "Immunoregulation in leishmaniasis" will determine immunological events occurring early after the contact of leishmania with macrophages, the role of cytokines (GM-CSF and IL-12) as vaccine adjuvants and the immunological and clinical responses related to treatment of cutaneous leishmaniasis with IL-12 in combination with pentavalent antimony. Project IV. "Role of Cytokines, Cellular Immunologic Determinants and New Approaches to Treating Persistent diarrhea in population at high risk for Crytosporidium, enteroaggregative E. coli and other enteric infections" will define the role of enteric cytokines and cellular immunity in the physiologic derangements in persistent cryptosporidal, E. coli and other diarrhea illnesses and to examine novel, function-based approaches to their therapy.