METFORMIN IN OBESE ADOLESCENTS PREDISPOSED TO TYPE II DIABETES

患有胰岛素抵抗的肥胖青少年易患 成年后发生II型糖尿病。 本研究 研究二甲双胍对肥胖患者胰岛素敏感性的影响， 空腹胰岛素水平升高的青少年， 2型糖尿病患者的家属 该试验是双盲和安慰剂 控制。 肥胖青少年将接受快速静脉注射葡萄糖 耐受性试验，允许对胰岛素敏感性进行基线评估 使用Bergman最小模型 然后将为患者分配药物 或安慰剂组共6个月，监测空腹 血糖、胰岛素、糖化血红蛋白、血脂和 体重、血压和全身脂肪。 胰岛素敏感性将是 在试验结束时通过重复静脉葡萄糖 耐受性试验 这些研究的结果可能会提供一种新的方法 在易患糖尿病的患者中预防糖尿病 疾病

Obese adolescents with insulin resistance are predisposed to the development of Type II diabetes mellitus in adulthood . This study examines the effects of Metformin on insulin sensitivity in obese adolescents with elevated fasting insulin levels and first degree relatives with Type II diabetes. The trial is double-blind and placebo controlled. Obese adolescents will undergo a rapid intravenous glucose tolerance test, permitting baseline assessment of insulin sensitivity using the Bergman minimal model. Patients will then be assigned to drug or placebo groups for a total of six months, with monitoring of fasting plasma glucose, insulin, glycosylated hemoglobin, plasma lipids and weight, blood pressure and total body fat. Insulin sensitivity will be assessed at the end of the trial by repeating the intravenous glucose tolerance test. The results of these studies may provide a new approach to the prevention of diabetes mellitus in patients predisposed to the disease.