Dissecting the role of RYK in cortical neuron specification and schizophrenia

在新皮层内正确产生神经元亚型对于协调大脑活动和高阶功能至关重要。了解新生神经元如何决定采用哪种亚型是至关重要的，因为不正确的神经元身份对新皮质功能有深远的影响，并与精神分裂症和精神残疾有关。我们最近发现一种分子RYK与精神分裂症有关。在这个项目中，我们将探索Ryk如何影响皮质神经元的命运。

Correct production of neuronal subtypes within the neocortex is essential for coordinated brain activity and higher-order functions. Understanding how newborn neurons decide which subtype to adopt is critical as incorrect neuron identity has profound consequences for neocortical function and is associated with schizophrenia and mental disability. We have recently linked one molecule, RYK, to schizophrenia. In this project we will explore how Ryk influences cortical neuron fate.