REPBASE--A DATABASE OF REPETITIVE SEQUENCES

描述：（摘自项目摘要）重复DNA代表 超过50%的真核生物基因组，并含有大量的 关于基因组结构和进化的信息。 它的知识是 对于理解复杂的关系至关重要 基因蓝图和它们的生物功能 也具有 对基因组作图和测序项目具有实际意义。 不可避免的是，研究人员研究了越来越多的DNA序列， 未来几年将不得不分析越来越多的重复 元素在不断增长的细节中融入其中。 存在 至少有三个主要方面的研究：（一）自动注释 使用已知重复序列的参考集合的重复DNA 和专门的计算机软件;（ii）特定重复序列的评估 基于现有的生物信息，以及（iii）其他 专门研究涉及序列背景和性质的 重复。 这些研究将需要电子版， 不断更新的包含重复序列参考集合的数据库， 参考重复的描述以浓缩形式组织，以及 专门的收藏品，可以详细研究现有的 同源重复序列 第一个重复DNA数据库， “Repbase”是我们集团在1992年发行的。 在这里我们建议 进一步采取必要措施，改善和加强这一资源。 我们 具体目标包括： 1. 开发和维护重复元素的参考集合 所有已测序的真核生物 2.启动一个同行审查的电子百科全书， 重复DNA的关键信息 3.开发和维护重复DNA的二级收集。

DESCRIPTION: (Taken from project abstract) Repetitive DNA represents over 50% of eukaryotic genomes and contains a tremendous wealth of information about genomic structure and evolution. Its knowledge is of crucial importance for understanding complex relationships between genetic blueprints and their biological functions. It is also of practical significance for genome mapping and sequencing projects. Inevitably, researchers studying growing numbers of DNA sequences in the coming years will have to analyze increasing numbers of repetitive elements integrated within them in ever growing detail. There are at least three major aspects of such studies: (I) automatic annotation of repetitive DNA using reference collections of sequences of known repeats and specialized computer software; (ii) evaluation of particular repeats based on the existing biological information, and (iii) other specialized studies involving sequence context and properties of the repeats. Such studies will require electronically available and constantly updated database containing reference collections of repeats, description of the reference repeats organized in a condensed form, and specialized collections allowing detailed studies of available homologous repeats. The first database of repetitive DNA known as "Repbase" has been released by our group in 1992. Here we propose further steps necessary to improve and enhance this resource. Our specific goals include: 1. Develop and maintain reference collections of repetitive elements from all sequenced eukaryotic species. 2. Initiate a peer-reviewed electronic encyclopedia containing, updated key information on repetitive DNA. 3. Develop and maintain secondary collections of repetitive DNA.