EFFECT OF AGE ON PANCREATIC BETA CELL RESPONSE TO CHANGES IN INSULIN SENSITIVITY

人类衰老与糖耐量异常和 胰岛素敏感性和年龄对胰岛β细胞功能的影响 人类并不清楚。健康年轻人中的胰岛β细胞 功能通过增加对胰岛素抵抗的敏感性来适应胰岛素抵抗 葡萄糖导致胰岛素分泌增加。胰岛素敏感性 可以被几种药物改变，其中一种是 诱导胰岛素抵抗并增强胰岛素的烟酸 健康年轻人的分泌反应。我们建议研究 青年和老年受试者的胰岛素分泌反应 而不损害糖耐量)烟酸前后 用来检验衰老导致受损的假说的管理 胰岛β细胞对胰岛素抵抗的适应性。

Human aging is associated with glucose intolerance and changes in insulin sensitivity but age effects on pancreatic beta cell function in humans are not clear. In healthy young people pancreatic beta cell function adapts to insulin resistance by increasing sensitivity to glucose resulting in increased insulin secretion. Insulin sensitivity can be changed by several pharmacological agents one of which is nicotinic acid which induces insulin resistance and enhances insulin secretion responses in healthy young adults. We propose to study insulin secretion responses of young and elderly subjects (with and without impaired glucose tolerance) before and after nicotinic acid administration to test the hypothesis that aging causes impaired pancreatic beta cell adaptation to insulin resistance.