HORMONAL,VISUAL & NEUROPSYCHOLOGIC DYSFUNCTION IN PITUITARY HYPOTHALAMIC DISEASE

该项目的目的是更好地定义发病率，解剖 相关因素、病理生理学、自然史或对治疗的反应 激素、视觉和神经心理功能障碍 肿瘤、头部创伤或涉及垂体的其他病理， 下丘脑在每一个病人，一组垂体前叶，后叶 垂体，视觉，神经心理学和MRI测试将在之前进行， 在手术、放射或药物治疗后间隔6-24个月。 治疗类型将由患者接受治疗的医生选择。 提到。功能测试的结果将在 结合其他变量确定1）发生率和 存在的功能障碍类型; 2）它们与位置的相关性（如果有的话） 3）与随后的临床表现的关系 激素、视觉或神经心理功能紊乱;以及4） 随着时间的推移，随着不同的治疗方式而变化。我们预计 这些信息将改善患者的管理， 各种类型的垂体下丘脑疾病，也可能是 确定位置和/或功能的基本价值 调节这些重要活动的神经系统的组织。

The purpose of this project is to better define the incidence, anatomical correlates, pathophysiology, natural history, or response to treatment of hormonal, visual and neuropsychologic dysfunction(s) in patients with tumors, head trauma or other pathology involving the pituiary and hypothalamus. In each patient, a battery of anterior pituitary, posterior pituitary, visual, neuropsychologic and MRI tests will be given before and at 6-24 month intervals after surgical, radiologic or medical therapy. The type of therapy will be chosen by the physician to whom the patient was referred. The results of the functional tests will be analyzed in conjunction with the other variables to determine 1) the incidence and types of dysfunction present; 2) their correlation if any with the location of the lesion on MRI; 3) their relationship to subsequent clinical disturbances of hormonal, visual or neuropsychologic function; and 4) their change over time following different kinds of treatment. We anticipate that the information outlined will improve the management of patients with various types of pituitary hypothalamic disease, and may also be of fundamental value in determining the location and/or functional organization of the neuronal systems that regulate these vital activities.