E2 AND GH EFFECT ON PROTEIN SYNTHESIS AND BONE DEPOSITION IN TURNER SYNDROME

骨质减少在特纳综合征中很常见。 尽管事实证明 EE[2]缺乏与骨质疏松症之间的关系，EE[2]治疗 不能使骨矿物质含量正常化。 使用 钙（Ca）的稳定同位素，我们测定了Ca吸收分数， 7名儿童（10-16岁）和4名成人的骨平衡和骨沉积 （16-34岁）特纳综合征。 每个科目之前都进行过研究 GH治疗3个月后（成人0.1 mg/kg/d， mg/kg/d）。 所有成人均接受EE治疗[2]（50 微克/天）和孕酮。 三 儿童未接受EE[2]，4名儿童接受低剂量治疗（5 微克/天）EE[2]与GH组合。 GH对Ca 已经服用EE[2]/孕酮方案的成人中的动力学 更换. 单独使用GH也不影响儿童的钙动力学。 然而，在儿童GH治疗中添加EE[2]导致 显著增加钙吸收、钙平衡和钙周转。 虽然这项研究没有检查EE[2]对Ca 动力学，我们得出结论，生长激素单独既不刺激骨沉积 也不影响特纳综合征儿童或成人的钙动力学。 然而，在GH方案中加入低剂量雌激素可能会改善 Turner综合征女孩的骨沉积和钙平衡

Osteopenia is common in Turner's syndrome. Despite the proven association between EE[2] deficiency and osteoporosis, EE[2] treatment in Turner's syndrome does not normalize bone mineral content. Using stable isotopes of calcium (Ca) we determined Ca fractional absorption, balance, and bone deposition in 7 children (10-16 y old) and 4 adults (16-34 y old) with Turner's syndrome. Each subject was studied before and after 3 months of GH treatment (0.1 mg/kg/d in adults and 0.05 mg/kg/d in children). All adults were treated with EE[2] (50 microgram/d) and progesterone before and throughout the study. Three children received no EE[2] and 4 children were treated with low dose (5 microgram/d) EE[2] in combination with GH. GH did not affect Ca kinetics in adults already taking a regime of EE[2]/progesterone replacement. GH alone also did not affect calcium kinetics in children. However, addition of EE[2] to GH treatment in children resulted in a significant increase in Ca absorption, Ca balance and Ca turnover. Although this study did not examine isolated effects of EE[2] on Ca kinetics, we conclude that GH alone neither stimulates bone deposition nor influences Ca kinetics in children or adults with Turner's syndrome. However, addition of low dose estrogen to a regimen of GH may improve bone deposition and calcium balance in girls with Turner's syndrome.