COCAINE SENSITIVE DOPAMINE TRANSPORTER SYNTHESIS

多巴胺转运蛋白是可卡因的关键靶点或“受体” 介导其成瘾特性。 因此了解 控制大脑中多巴胺转运蛋白水平的因素是 对了解药物成瘾的机制至关重要。 这 项目计划开发一种方法来测量合成率， 多巴胺转运蛋白和血清素的降解率 运输机也是。 血清素转运体很重要， 它是抗抑郁药物的靶点或受体。 实质性 已经取得了进展，血清素转运蛋白的周转， 它的半衰期是3.4天。 我们正在 确定多巴胺转运蛋白的相同因素。

The dopamine transporter is a key target or "receptor" for cocaine that mediates its addicting properties. Therefore, understanding the factors which control the levels of dopamine transporter in brain is essential for understanding mechanisms of drug addiction. This project plans to develop a method to measure the synthesis rate and degradation rate of the dopamine transporter, and the serotonin transporter as well. The serotonin transporter is important because it is a target or receptor for antidepressant drugs. Substantial progress has been made in that the serotonin transporter turnover has been measured and its half-life is 3.4 days. We are in the process of determining the same factors for the dopamine transporter.