ROCHESTER AREA PEPPER CENTER

罗切斯特地区胡椒中心(RAPC)的更新建立在 过去3年以上的工作经验。目前RAPC的2次干预 (IS)和2项干预发展(IDS)研究，重点是评估 如何改善或维持老年人的功能状态 不同阶段的身体依赖使用标准运动或 慢性阻塞性肺疾病的药物干预及治疗前后方法 功能评估。取得了很好的进展，出版了23份出版物 来自ID或ID，93来自RAPC教职员工的研究，49来自工作 由刚果民盟资助。尽管过去取得了进展，但新提案进入了一个新的阶段 方向。我们将把基础机制研究整合到3个临床项目中 入侵检测系统。IDS#1扩大了我们在急性呼吸道疾病中的成功 在虚弱的老年人中进行感染(ARTI)以确定在 免疫学和血栓状态是导致或促成 ARTI中注意到的功能衰退。IDS#2建立在当前IS调查结果的基础上 显示抗阻运动训练并未有大的改善 健康老年人的肌原纤维蛋白合成。新目标 是为了确定肌原纤维蛋白的比例是否更年轻 性腺类固醇治疗将导致合成，从而将 年龄相关性骨骼肌萎缩。在入侵检测系统#3中的补充方法 将被用来研究与疾病或年龄相关的神经功能下降 空间定向和均衡控制的机制。这些 方法包括站立平衡(姿势控制)、眼睛-头部和眼睛- 头-手协调，以及区别于 自我远离外部发起的运动。其目标是澄清 维持和影响感觉-运动整合的参数 主体和环境。研究开发(RD)，研究资源； [生物统计学(RRB)]、示范和信息传播(DID)、 和管理(LA)核心构成了所有RAPC功能。这些核心 A)为新倡议提供种子资金并支持职业 初级教师的发展(RD)；b)提供准确的方法(RRA) 检测入侵检测系统的谷胱甘肽代谢和其他正在进行的研究；c) 协助实验设计和数据统计分析(RRB)； D)向医学界和非医学界通报皇家儿科委员会的工作，并宣传 它的教育方案(DIDC)；以及e)提供领导， 实现以下目标所需的行政结构和监督(LA) 入侵检测系统和核心。开发新的RAPC所遵循的原则是 它的研究和功能，与正在进行的临床相关并做出贡献 和R大学医学中心的研究计划，从而加强 中心的作用和意义。

The renewal of the Rochester Area Pepper Center (RAPC) builds on the experience of the previous 3 + years. The current RAPC's 2 intervention (IS) and 2 intervention development (IDS) studies focused on evaluating ways to improve or maintain the functional status of the elderly at various stages of physical dependency using standard exercise or pharmacologic interventions and pre- and post-treatment methods of functional assessment. Excellent progress has resulted in 23 publications from the IDs or IDSs, 93 from research of RAPC faculty, and 49 from work funded by the RDC. Despite past progress, the new proposal moves in a new direction. We will integrate basic mechanistic research into 3 clinical IDSs. IDS#1 extends our successful IS of Acute Respiratory Tract Infections (ARTI) in the frail elderly to determine if alterations in immunologic and thrombotic status are predisposers or contributors to, the functional decline noted in ARTI. IDS#2 builds on the current IS findings showing that resistance exercise training does not greatly improve myofibrillar protein synthesis in healthy elderly subjects. The new goal is to determine if a 'more youthful' rate of myofibrillar protein synthesis will result from gonadal steroid therapy thus minimizing the age-related skeletal muscle atrophy. In IDS#3 complementary approaches will be used to study the disease- or age-related declines in neural mechanisms governing spatial orientation and equilibrium control. These approaches include standing balance (postural control), eye-head and eye- head-hand coordination, and visual motion processing that distinguishes self- from externally -initiated movements. The goal is to clarify the parameters that maintain and influence sensory-motor integration between subject and environment. Research Development (RD), Research Resource ; [Biostatistics (RRB)], Demonstration and Information Dissemination (DID), and Administrative (LA) Cores contribute to all RAPC functions. The Cores a) provide seed money for new initiatives and to support the career development of junior faculty (RD); b) provide methods (RRA) for accurate assay of glutathione metabolism for the IDS and other ongoing research; c) assist in the experimental design and statistical analysis of data (RRB); d) inform the medical and lay communities of the RAPC's work and publicize its educational programs (DIDC); and e) provide the leadership, administrative structure and oversight (LA) needed to fulfill the goals of the IDS and Cores. The abiding principle in developing the new RAPC was that its studies and functions, relate and contribute to ongoing clinical and research programs at the U of R Medical Center thereby enhancing the Center's function and significance.