EFFECT OF ALPHA MSH ON INFLAMMATION

一些长期接受透析治疗的患者会出现食欲减退，虚弱， 高血压、β2微球蛋白蓄积和频繁感染。 这些并发症中的许多被认为是由于激活 通过与透析器接触使炎症细胞循环 薄膜。这些被激活的细胞会产生一种叫做促红细胞生成素的物质 炎性细胞因子被认为增加了细胞的分解 肌肉组织并引起上述全身症状。本研究 将研究α-黑素细胞刺激素对 透析患者细胞因子的产生。中国的实验室证据 培养的细胞和整个动物表明α-MSH可以抑制 在多种形式的炎症中产生促炎细胞因子。 我们建议确定α-MSH是否可以预防炎症状态 通过透析诱导，从而减少短期和长期副作用 效果。

Some patients on long-time dialysis therapy suffer anorexia, wasting, hypertension, beta2 microglobulin accumulation, and frequent infections. Many of these complications are thought to be caused by activation of circulating inflamatory cells through contact with the dialyzer membrane. The activated cells produce substances called pro- inflammatory cytokines which are thought to increase breakdown of muscle tissue and cause systemic symptoms as listed above.This study will examine the action of alpha-Melanocyte Stimulating Hormone on cytokine production in dialysis patients. Laboratory evidence in cultured cells and whole animals indicate that alpha-MSH can inhibit production of pro-inflammatory cytokines in many forms of inflammation. We propose to determine if alpha-MSH can prevent the inflammatory state induced by dialysis and thereby, reduce short-term and long-term side effects.