SOFTWARE DEVELOPMENT & DISTRIBUTION

已经开发并分发了两个软件包LYSIS 适应。 这两个软件包都在不断扩展， 纳入核心项目1、2和 #5. LYSIS是一个交互式模块化软件包的程序 执行可用于线性和非线性的高级任务 时间序列分析、系统建模与仿真。 最新 版本6.2包括“主动态模式”分析技术 以及一种新型的“人工神经网络”，两者都是在1989年开发的。 核心项目#1。 这些程序是LYSIS独有的， 许多生物医学领域的数据分析能力 应用. 此外，沃尔泰拉独特的LYSIS程序 将核估计转换为MatLab工具集， 促进其在同行社区中更广泛的使用。 在过去 在赠款年度，我们继续分发和支持 适应。 版本4包括：广泛的模型文件库，其中包含 重要的药代动力学和药效学模型;完全错误 ID中极大似然估计的分析;信息 每个估计量的模型选择标准;扩展预测 统计和残差分析;用户定义的次要参数 模型;适应性试验的部分优化抽样计划 设计;自动多受试者参数估计。 第4版 支持以下硬件/软件平台： PC/Windows 95/NT（Digital Visual Fortran v.5.0）; PC/Windows 3.1（DOS） （Microsoft PowerStation Fortran v 1.0）; SUN/Solaris; VAX/OpenVMS; HP/HP-UX（可根据要求提供）。 第4版用户指南 包括使用ADAPT建模的教程介绍。 此外， 广泛的模型库，包括超过35个 药代动力学和药代动力学/动力学模型。 这些库 模型在用户指南中有完整的文档， 用户手册中包含的众多示例运行中说明了 为着力

Two software packages have been developed and distributed LYSIS and ADAPT. Both software packages are continuously expanded to incorporate new methodologies developed in Core Projects #1, #2 and #5. LYSIS is an interactive modular software package of programs performing high-level tasks that can be used for linear and nonlinear time-series analysis, and system modeling and simulation. The latest Version 6.2 includes the "principal dynamic mode" analysis technique and a novel class of "artificial neural networks", both developed in Core Project #1. These programs are unique to LYSIS and enhance significantly the data analysis capabilities in many biomedical applications. In addition, the unique LYSIS programs of Volterra kernel estimation were converted into MatLab toolset in order to promote their broader use among the peer community. During the past grant year we have continued the distribution and support Release 4 of ADAPT. Release 4 includes: extensive Model File Library containing important pharmacokinetic and pharmacodynamic models; complete error analysis for the maximum likelihood estimator in ID; information criteria for model selection with each estimator; expanded predictive statistics and residual analysis; user defined secondary parameter models; partially optimized sample schedules for adaptive trial designs; automated multiple subject parameter estimation. Release 4 is supported for the following hardware/software platforms: PC/Windows 95/NT (Digital Visual Fortran v. 5.0); PC/Windows 3.1 (DOS) (Microsoft PowerStation Fortran v 1.0); SUN/Solaris; VAX/OpenVMS; HP/HP-UX (available upon request). The User's Guide for Release 4 includes a tutorial introduction to modeling with ADAPT. Also, an extensive Model Library is available that includes over 35 pharmacokinetic and pharmacokinetic/dynamic models. These library Models are fully documented in the User's Guide and many are illustrated in the numerous example runs contained in the User's Guide.