BONE DENSITY AND FOREARM FRACTURES IN INJURED CHILDREN

描述（改编自申请人的摘要）：骨折在 对儿童骨骼健康构成直接威胁。 前臂远端是儿童最常见的骨折部位（1/9 儿童在童年和青春期前臂骨折）。最近 人们的注意力集中在增加儿童的骨密度， 骨质疏松症的症状骨骼特性是否有助于 在其他方面健康的儿童中骨折风险是未知的。的关系 骨矿化和骨折风险尚不清楚，因为骨矿物质含量和 随着年龄的增长，骨密度沿着增加，骨折的风险也随之增加。本研究将 检查骨质量和密度之间的关系和几何特性， 儿童和青少年的骨骼和前臂骨折的风险 损伤本建议的具体目的是：（1）确定骨 密度与儿童和青少年的前臂骨折风险有关， 经历创伤;（2）确定骨质、密度或几何形状 测量最能区分骨折儿童和骨折儿童 不是骨折。这些问题将通过以下病例对照研究来解决： 320名5-16岁的儿童和青少年受伤 并在儿童医院医疗中心进行了评估，怀疑 前臂骨折前臂骨折的骨量、骨密度和骨几何形态 将对病例和非骨折受伤对照进行比较。身体活动 将对模式和饮食摄入进行评估，以便调查 这些因素是否以及如何与骨测量和骨折相关 风险该项目将评估增加骨密度的重要性， 不同的骨骼几何形状，以预防健康人前臂骨折 儿童谁经历受伤，并将确定最佳的骨骼测量， 预测前臂骨折和这种测量的决定因素。 识别最具预测性的骨测量值非常重要， 可用作旨在增加骨密度的干预试验的终点 在儿童中的质量和密度。理解这些决定因素 测量将为促进骨骼健康和减少 儿童骨折风险。

DESCRIPTION (Adapted from the Applicant's Abstract): Fractures are common in childhood and constitute the major immediate threat to bone health in children. The distal forearm is the most common site of fracture in children (1 in 9 children sustain a forearm fracture during childhood and adolescence). Recent attention has focused on increasing bone density in children for the prevention of osteoporosis several decades later. Whether skeletal properties contribute to fracture risk in otherwise healthy children is unknown. The relation between bone mineralization and fracture risk is not clear, as bone mineral content and density increase with age along with the risk of fracture. This study will examine the relation between bone mass and density and geometric properties of bone and risk of forearm fracture in children and adolescents who experience injury. The Specific Aims of this proposal are: (1) to determine whether bone density is related to forearm fracture risk in children and adolescents who experience trauma; (2) to determine which bone mass, density or geometric measurement best discriminates between children who fracture and those who do not fracture. These questions will be addressed with a case-control study of 320 children and adolescents between 5-16 years of age that experience injury and have been evaluated at Children's Hospital Medical Center for suspicion of forearm fracture. Bone mass, density and bone geometry of forearm fracture cases and non-fractured injured controls will be compared. Physical activity patterns and dietary intake will be assessed to allow investigation as to whether and how these factors are related to bone measurements and fracture risk. This project will evaluate the importance of increased bone density and differences in bone geometry for preventing forearm fractures in healthy children who experience injury, and will identify the best bone measurement for predicting forearm fractures and the determinants of this measurement. Identification of the most predictive bone measurement is important so that it can be used as an endpoint in intervention trials designed to increase bone mass and density in children. Understanding the determinants of this measurement will inform strategies to promote healthy bone and decrease fracture risk in childhood.