NON-INVASIVE IMAGING OF INFLAMMATION IN ASTHMA

哮喘是一种呼吸道炎症性疾病；因此，抗炎药物，例如吸入皮质类固醇，现在是治疗哮喘的核心。量化炎症的非侵入性技术，如痰细胞学，尚未得到广泛接受，也不能提供哮喘性炎症的解剖定位。本项目拟将正电子发射断层扫描（PET）应用于这些问题。迄今为止，我们已经使用[18F]氟- d葡萄糖（FDG）和高分辨率PET扫描仪检查了8例哮喘患者和6例非过敏、非哮喘患者的PET扫描。初步结果表明，从肺组织PET扫描获得的大部分信号可归因于血液而不是肺部炎症。在这些研究中，哮喘受试者有较大的肺血容量。-哮喘，炎症，治疗，正电子发射断层扫描，解剖学，肺功能-人类受试者

Asthma is an inflammatory disease of the airways; as such, anti- inflammatory drugs, for example inhaled corticosteroids, are now central to the treatment of asthma. Non-invasive techniques to quantify inflammation, such as sputum cytology, have not gained widespread acceptance and do not provide anatomic localization of asthmatic inflammation. This project proposes to apply positron emission tomography (PET) to these questions. To date, we have examined PET scans of 8 asthmatic and 6 non-allergic, non-asthmatics donors employing [18F]fluoro-D glucose (FDG) and a high resolution PET scanner. Initial results demonstrate that a large fraction of the signal obtained from PET scanning from lung tissue is attributable to blood rather than pulmonary inflammation. Asthmatic subjects had a larger pulmonary blood volume noted in these studies. - Asthma, inflammation, therapy, positron emission tomography, anatomy, pulmonary function - Human Subjects