ADVERSE EFFECTS OF OXIDATIVE STRESS DURING PREGNANCY

工作总结：氧化损伤与几种疾病的病理学有关，我们已经证明它可能是不良妊娠结局的一个因素。对人类的研究受到难以测量大量人群的氧化应激的限制。我们一直致力于两个目标：解决氧化应激标志物的变异量，并通过确定敏感，特异性和临床相关的措施，适合现场使用的脂质过氧化在生殖问题中的作用的大规模流行病学研究做准备。今年，我们发表了关于抗氧化剂和氧化状态标志物的变异性的研究结果，这些变异性是由于季节性和个体内变异以及储存程序造成的;我们比较了孕妇和非孕妇的这些变异性。我们还调查了文献，这是多样的，难以访问，并发表了脂质过氧化和怀孕的审查。我们继续与BOSS科学家小组合作，以确定有用的氧化应激流行病学标志物。我们在氧化应激和妊娠方面的工作因失去我们在保加利亚的首席合作者而大大放缓，他已经接受了USNCTR的职位。- 氧化应激，脂质过氧化，妊娠，生殖，标志物，变异性，综述-人类受试者

Summary of Work: Oxidative damage has been implicated in the pathology of several diseases, and we have shown that it may be a factor in adverse pregnancy outcomes. Studies in humans are limited by the difficulty of measuring oxidative stress in large numbers of people. We have been working with two aims: To resolve the amount of variability in oxidative stress markers, and to prepare for a large-scale epidemiologic study of the role of lipid peroxidation in reproductive problems by identifying sensitive, specific, and clinically relevant measures that are suitable for field use. This year we published our findings on the variability of markers of anti-oxidant and oxidant status due to seasonal and intra-individual variation and to storage procedures; we compared these in pregnant and non-pregnant women. We also surveyed the literature, which is diverse and difficult to access, and published a review of lipid peroxidation and pregnancy. We continue to work with the BOSS group of scientists to identify useful epidemiologic markers of oxidative stress. ADDITIONAL INFORMATION Our work in oxidative stress and pregnancy has been considerably slowed by the loss of our chief collaborator in Bulgaria, who has accepted a position with the USNCTR. - Oxidative stress, lipid peroxidation, pregnancy, reproduction, markers, variability, review - Human Subjects