GENETIC SUSCEPTIBILITY AND THE ENVIRONMENT IN CANCER RISK

工作总结：这项研究测试了一种假设，即通常遗传的某些基因的等位基因变异，与环境暴露一起，影响一个人患疾病的风险。这项工作的主要重点是膀胱癌和前列腺癌，还有关于肺癌和脑膜瘤的新研究。尽管过去的研究主要集中在受体和致癌物代谢基因的多态性上，但我们越来越多地将精力集中在DNA修复基因的多态性上，并致力于开发可应用于基于人群的样本的DNA修复功能分析方法。我们最近发表了第二项关于VDR受体多态性与前列腺癌风险的研究结果，并与贝尔实验室合作，研究了参与雄激素代谢的两个基因--CYP17和SRD5A2--与前列腺癌风险相关。在与Devereux女士的合作中，我们提交了一份手稿，描述了对p16基因新的多态的搜索，以及选定的多态与膀胱癌风险的病例对照比较结果。在《暴露性突变关键靶基因》中描述的一项新研究也包含与遗传易感性有关的中心成分。这项研究包括荧光支气管镜检查和异常支气管病变的分子表征：高危患者早期检测肺癌的新方法获得正常血液，用于癌症患者和对照的选定DNA修复基因的基因分型，并包括收集正常的支气管上皮，用于体外测量目标组织的DNA修复能力。-遗传易感性、分子流行病学、膀胱癌、多态、前列腺癌、肺癌-人类受试者和人类受试者：仅采访、问卷或调查

Summary of Work: This research tests the hypothesis that commonly inherited allelic variants of certain genes, in conjunction with environmental exposures, affect a persons risk of developing disease. The primary focus of this work has been on bladder cancer and prostate cancers, with new studies in lung cancer and meningioma. Although the primary focus of past research has been on polymorphisms in receptors and carcinogen metabolism genes, we are increasingly focusing our efforts on polymorphisms in DNA repair genes and on the development of functional assays for DNA repair that can be applied in population- based samples. We have recently published the results of a second study on the VDR receptor polymorphism and prostate cancer risk, and in collaboration with the Bell laboratory on two genes involved in androgen metabolism, CYP17 and SRD5A2, in relation to prostate cancer risk. In collaboration with Ms. Devereux we have submitted for publication a manuscript describing a search for new polymorphisms in the p16 gene and the results of a case-control comparison for selected polymorphisms and bladder cancer risk. a new study described in Exposure-specific mutation in critical target genes also contain central components relating to genetic susceptibility. The study Fluorescence bronchoscopy and molecular characterization of abnormal bronchial lesions: novel approaches for early detection of lung cancer in high-risk patients obtains normal blood for genotyping of selected DNA repair genes in cancer cases and controls and includes the collection of normal bronchial epithelium for in vitro measurement of DNA repair capability in target tissue. - genetic susceptibility, molecular epidemiology,bladder cancer, polymorphism, prostate cancer, lung cancer - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only