CHRONIC DISEASE RISKS ASSOCIATED WITH MERCURY VAPOR EXPOSURE

工作总结：我们正在与国家糖尿病、消化和肾脏疾病研究所以及美国牙科协会的研究人员合作，研究接触汞和一氧化二氮的牙医患终末期肾脏疾病的风险。我们正在将1977年之前毕业的13.8万名美国牙医与美国肾脏疾病登记处进行比较，看看高度接触汞的普通牙医是否比接触汞较少的正畸医生和其他专科医生有更高的肾衰竭发生率。我们还将观察口腔外科医生和儿科医生是否增加了一氧化二氮暴露的风险。初步分析表明，与牙科专家相比，普通牙科医生患ESRD的风险更高，这与研究假设一致。我们正在撰写ESRD研究的结果，以及使用NHANES I数据研究牙科汞齐与血压之间的关系的早期研究。-牙科、汞、肾脏疾病、儿童发育、高血压、高血压、汞蒸气-人类受试者：仅访谈、问卷或调查

Summary of Work: We are collaborating with researchers from the National Institute of Diabetes and Digestive and Kidney Diseases and the American Dental Association of the risk of end stage renal disease among dentists exposed to mercury and nitrous oxide. We are comparing 138,000 U.S. dentists who graduated before 1977 with the U.S. renal disease registry to see whether general dentists who are highly exposed to mercury have higher rates of renal failure than orthodontists and other subspecialties who have lower exposures. We will also look whether oral surgeons and pedodontists who have elevated nitrous oxide exposures have increased rates. Initial analyses suggest that there is an excess risk of ESRD among general dentists compared to dental specialists which is consistent with the study hypothesis. We are writing up the results of the ESRD study and an earlier study looking at the relationship between dental amalgam and blood pressure using NHANES I data. - dental, mercury, renal disease, childhood development, hypertension, high blood pressure, mercury vapor, - Human Subjects: Interview, Questionaires, or Surveys Only