FMRI task design and statistical analysis software

描述（由申请人提供）：该项目的总体目标是 开发新一代功能性MRI设计和分析软件。的 所提出的软件旨在导致一个数量级的改进， 目前的方法在估计和检测功能磁共振成像激活。 该软件将生成最佳的快速呈现事件相关（RPER）功能磁共振成像 的设计.这样的设计允许新类别的功能成像实验 并允许功能磁共振成像和传统的电生理或 行为研究 该软件还将纳入方法，大大增加统计 检测任务相关生理反应的能力和可靠性， fMR 1，包括使用相关噪声补偿，以及最佳空间 过滤这些方法将适用于阻塞和事件相关的 范例 虽然该软件将是可用的，并在一个独立的版本，它 也将被设计为与我们的结构MRI套件互操作， 软件工具。特别是，结果将能够在 扁平和膨胀的皮质软带，可实现上级可视化。该地区 多模态脑成像（fMRI，EEG，MEG）将大大推进， 支持快速呈现事件相关设计和皮质表面 在一个单一的计算平台上。 拟定商业应用： 使用功能性MRI的研究人员会对拟议产品感兴趣，即，全世界有超过1000个，并且迅速发光。该软件将使功能性磁共振成像的功能增加至少20%，但我们建议仅以功能性磁共振成像设备成本的0.1%出售。换句话说，拟议中的软件可以将达到给定显著性水平所需的功能磁共振成像会话数量减半，因此大约10次会话后就可以收回成本。

DESCRIPTION (Provided by Applicant): The overall goal of the project is to develop a new generation of functional MRI design and analysis software. The proposed software is designed to lead to an order of magnitude improvement over current methods in the estimation and detection of fMRI activation. The software will generate optimal rapid-presentation event-related (RPER) fMRI designs. Such designs allow for new classes of functional imaging experiments and permit comparisons between fMRI and traditional electrophysiological or behavioral studies. The software will also incorporate methods to greatly increase the statistical power and reliability for detecting task-related physiological responses with fMRl, including the use of correlated noise compensation, and optimal spatial filtering. These methods will be applicable to both blocked and event-related paradigms. While the software will be usable and available in a stand-alone version, it will also be designed to be interoperable with our suite of structural MRI software tools. In particular, the results will be able to be presented on flattened and inflated cortical sw-laces for superior visualization. The area of multi-modal brain imaging (fMRI, EEG, MEG) will be greatly advanced by supporting rapid-presentation event-related designs and cortical surface formats within a single computational platform. PROPOSED COMMERCIAL APPLICATION: The proposed product would be of interest to researchers using functional MRI, i.e., over 1000 worldwide and glowing rapidly. The proposed software will increase the functionality of fMRI by at least 20% but we propose to sell it for only about 0.1% of the fMRI equipment cost. Put another way, the proposed software could halve the number of fMRI sessions needed to achieve a given level of significance, and thus would pay for itself after about 10 sessions.