Breast oncology program

描述：（申请人的描述）乳腺肿瘤学计划包括58名教职员工和乳腺癌倡导者。 四个主要的计划赠款和许多个人发起的赠款支持该计划。 这些赠款涵盖流行病学，成像，遗传学，生物学，治疗学和多学科临床癌症管理方面的工作。乳腺肿瘤学计划是仿照湾区乳腺癌孢子，也就是说，它包括合作的临床，人口，实验室研究人员和乳腺癌倡导者共同努力，有效地将实验室和人口研究转化为改善癌症管理和控制。 乳腺肿瘤学研究旨在开发先进的成像程序，以确定肿瘤范围和量化对治疗的反应;确定基因组，流行病学或生物标志物，定义和/或预测疾病进展或对治疗的反应;开发针对特定遗传或生物靶点的新疗法;并阐明肿瘤发生，进展或对治疗反应的机制。此外，大量的努力致力于开发一个临床环境，指导，支持和促进实验室和人口转化为改善临床护理。 乳腺癌管理的结果评估和建模是这一过程的重要组成部分。 这些领域和其他领域的研究是通过方案赞助的发展赠款来促进的。 讨论论坛包括每周一次的SPORE和计划项目研讨会;年度乳腺肿瘤学计划务虚会;非正式的下午讨论组;每周乳腺肿瘤委员会会议;国防部赞助的临床研究者季度会议;每月社区论坛;和患者-医生管理讨论系列。

Description: (Applicant's Description) The Breast Oncology Program comprises 58 faculty members and Breast Cancer Advocates. Four major program grants and numerous individual investigator-initiated grants support the Program. These grants cover work in epidemiology, imaging, genetics, biology, therapeutics, and multidisciplinary clinical cancer management. The Breast Oncology Program is modeled after the Bay Area Breast Cancer SPORE, that is, it comprises collaborating clinical, population, laboratory researchers, and Breast Cancer Advocates working together to effectively translate laboratory and population research in breast into improved cancer management and control. Breast Oncology research is aimed at developing advanced imaging procedures to define tumor extent and quantify response to therapy; identifying genomic, epidemiological, or biological markers that define and/or predict disease progression or response to therapy; developing new therapies directed against specific genetic or biologic targets; and elucidating mechanisms through which tumors arise, progress, or respond to therapy. In addition, substantial effort is devoted to developing a clinical environment that guides, supports, and facilitates translation of laboratory and population into improved clinical care. Outcome assessment and modeling of breast cancer management are important components of this process. Research in these and other areas is stimulated through Program-sponsored developmental grants. Discussion forums include weekly SPORE and Program Project seminars; an annual Breast Oncology Program retreat; an informal afternoon discussion group; weekly Breast Tumor Board conferences; DOD-sponsored quarterly meetings of clinical investigators; monthly community forums; and patient-physician management discussion series.