Dopamine, frontal-subcortical circuits and risk for schizophrenia

精神分裂症是一种使人衰弱的精神障碍，其特征是精神病性经历和情感和认知困难。该项目将绘制出特定大脑回路的中断与精神分裂症风险之间的关系，并使用遗传建模技术来了解大脑中特定化学物质多巴胺的失调如何导致这些变化。这项工作将对开发新的、更有针对性的治疗方法具有重要意义。

Schizophrenia is a debilitating mental disorder characterized by psychotic experiences and emotional and cognitive difficulties. This project will map how disruptions of specific brain circuits relate to risk for schizophrenia and use genetic modeling techniques to understand how dysregulation of a specific chemical in the brain, dopamine, might cause these changes. This work will have important implications for developing new, more targeted treatments.