ECHOCARDIOGRAPHY FOR THE STRONG HEART STUDY

在此期间，强心家庭研究的试点阶段已经成功完成，有31个三代扩展家庭的920名成员参加了研究。这些人和大约2900名强心脏研究的其他成员正在接受颈动脉超声、无创动脉压波形记录和计算机心电图术的评估，所有这些都由GCRC的CDMAS协调。进展报告和研究结果摘要：最重要的新发现是：(1)美国印第安人的颈动脉粥样硬化患病率高于同龄的美国白人或黑人；(2)糖尿病导致动脉肥大和动脉粥样硬化；(3)通过计算机技术测量的心电图Q-T间期延长和ST段压低独立于标准危险因素预测心血管死亡；(4)女性的左心室射血分数和其他左室功能指标低于男性；(5)左室质量和主动脉大小具有很强的遗传性，与公认的对其生长的刺激无关；(6)糖尿病对左室舒张功能有不利影响，与所有公认的危险因素无关。

During this period the pilot phase of the Strong Heart Family Study has been completed successfully with enrollment of 920 members of 31 extended 3-generation families. These individuals and approximately 2,900 additional members of the Strong Heart Study are undergoing assessment by carotid ultrasonography, non-invasive arterial pressure waveform recording and computerized electrocardiography, all of which are coordinated by CDMAS of the GCRC. Progress report and summary of findings: The most important new findings are: (1) American Indians have a higher prevalence of carotid atherosclerosis than White or Black Americans of the same age; (2) Diabetes causes arterial hypertrophy and atherosclerosis; (3) Prolongation of the Q-T interval of the electrocardiogram and ST segment depression measured by computerized techniques predict cardiovascular death independently of standard risk factors; (4) Left ventricular ejection fraction and other measures of ventricular function are lower in women than in men; (5) Left ventricular mass and aortic size are strongly heritable, independent of recognized stimuli to their growth; (6) Diabetes adversely affects left ventricular diastolic function, independently of all recognized risk factors.