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PHASE I PHARMACOKINETIC STUDY OF CARBOPLATIN IN COMBO WITH WEEKLY PACLITAXEL

PHASE I PHARMACOKINETIC STUDY OF CARBOPLATIN IN COMBO WITH WEEKLY PACLITAXEL
卡铂联合每周紫杉醇的 I 期药代动力学研究
批准号：
6219271
负责人：
CHANDRA BELANI
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219271
关键词：
carboplatin clinical research clinical trial phase I combination chemotherapy drug administration rate /duration drug adverse effect drug interactions drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy paclitaxel pharmacokinetics

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中文摘要
翻译
该研究的第一阶段要求卡铂每3周给药一次，紫杉醇每周一次。 紫杉醇的剂量强度可以通过每周给药显著增加，血液学毒性最小，此外，紫杉醇还可能对卡铂诱导的血小板减少症具有保护作用。 预期在该组合中增加紫杉醇的剂量强度将导致开发一种活性方案，而不会增加毒性，如在每3周一次的定期方案中所见。
英文摘要
Phase I of the study calls for a combination of carboplatin given every 3 weeks with weekly paclitaxel. The dose intensity of paclitaxel can be increased considerably by weekly administration with minimal hematological toxicity and in addition, paclitaxel may also have a protective effect on carboplatin induced thrombocytopenia. It is anticpated that the increased dose intensity of paclitaxel in this combination would result in developing an active regimen without added toxicity as seen on a regular every 3-week schedule.
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