ADHESION MOLECULES IN ADULT RESPIRATORY DISTRESS SYNDROME

我们假设，肺内多形核白细胞(PMN)边集(隔离)是急性呼吸窘迫综合征(ARDS)发生的重要早期事件，该事件受黏附分子的激活和表达调节。这项建议的总体目标是预测哪些高危患者将在进入呼吸窘迫阶段之前发展为ARDS。我们将利用广泛使用的放射性核素显像术，111-铟标记的自体白细胞，试图测量ARDS进展过程中不同器官，特别是肺的边缘形成。此外，我们还将确定PMN上黏附分子表达的变化是否与111-铟成像分析、临床状态相关，或者黏附分子表达本身是否可以用作预测工具。该方法包括招募一组有ARDS高危风险的患者。

We hypothesize that polymorphonuclear leukocyte (PMN) margination (sequestration) in the lung is an important early event in the development of the acute respiratory distress syndrome (ARDS) and that this event is regulated by the activation and expression of adhesion molecules. The overall objective of this proposal is to predict which high risk patients will develop ARDS before they enter a respiratory distress stage. We will take advantage of a widely used scintigraphic imaging procedure, 111-Indium labeled autologous white blood cells in an attempt to measure margination in various organs, particularly lung, during the progressive development of ARDS. Further, we will also determine if changes in adhesion molecule expression on PMN correlate with the 111-Indium imaging analysis, clinical status, or if adhesion molecule expression itself can be used as a predictive tool. The approach involves the recruitment of a select group of patients at high risk for developing ARDS.