CORE--NMR

分子核磁共振共享设施有以下目标：1.提供仪器，供UAB综合癌症中心成员在他们的研究计划中使用。2.通过服务和咨询，为癌症中心成员提供核磁共振专业知识。在之前的资助期间，85.5%的设施使用量是由癌症中心的教职员工使用的。这些教员在核磁共振设施进行的部分研究工作涉及：调节钙调蛋白活性的多肽的设计；用于放射性标记单抗的双功能螯合剂的设计；用作抗癌药物的核苷酸类似物的设计；干扰素-tau、神经氨酸酶、载脂蛋白片段的结构研究；蛋白多糖的生物合成；维甲酸的特性；糖基化对c-Myc的影响；使用RNA-DNA三联体进行抗基因治疗；病毒支架蛋白的结构研究；以及有效对抗胶质瘤的神经毒素。该设施的核磁共振系统也在升级，以向该设施的用户提供最先进的能力。建议核磁共振机构继续支持这些研究项目。

The Molecular NMR Shared Facility has the following objectives: 1. To provide instrumentation for use by the members of the UAB Comprehensive cancer Center in their research programs. 2. To provide NMR expertise to the Cancer Center members through service and consultation. During the previous funding period, 85.5% of the Facility usage was by Cancer Center faculty members. Some of the investigations conducted by these faculty members at the NMR Facility involved work on the design of peptides that regulate calmodulin activity, design of bifunctional chelating agents for radiolabeling monoclonal antibodies, design of nucleotide analogs as anti-cancer drugs, structural investigations on interferon-tau, neuraminidase, apolipoprotein fragments, biosynthesis of proteoglycans, characterization of retinoids, effect of glycosylation on c- Myc, anti-gene therapy using RNA-DNA triplexes, structural studies of viral scaffolding proteins, and neurotoxins effective against glioma. The NMR systems at the Facility are also being upgraded to provide state-of- the-art capabilities to the users of the Facility. Continued support of these research projects by the NMR Facility is proposed.