SYNTHESIS OF PHTHALOCYANINES FOR TUMOR PHOTOTHERAPY

酞菁作为光动力光敏剂有很大的应用前景 治疗，一种适用于癌症治疗的疗法。现在很明显 几种很有前途的新型酞菁或类酞菁 可以制造光敏剂。这导致了目前的提议。这个 这项提案的第一部分的目标是设计、综合和 描述用于PDT的特别有效的新型光敏剂 或者可以很容易地被生物消除。所有的光敏剂都是或 含有酞菁或类似酞菁的大环。的目标是 研究的第二部分是获取有关的基本信息 新化合物将光能转化为 会引发光动力破坏的化学活性物质。至 实现这一目标的一系列光物理和光化学 将对新化合物进行研究。这些研究将集中在 主要针对具有修饰的酞菁环的化合物，因为它 是预期的，内在的光敏能力， 它们中的酞菁生色团将以重要的方式不同于 复合到复合。

Phthalocyanines have much promise as photosensitizers for photodynamic therapy, a therapy applicable to cancer treatment. It is now apparent that several promising new types of phthalocyanine or phthalocyanine-like photosensitizers can be made. This has led to the present proposal. The goal of the first part of this proposal is to design, synthesize and characterize new photosensitizers for PDT that are particularly efficient or that can be easily bioeliminated. All the photosensitizers are or contain phthalocyanine or phthalocyanine-like macrocycles. The goal of the second part of the research is to obtain basic information as to the efficiency with which the new compounds transduce photoenergy into chemically reactive species that will initiate photodynamic damage. To achieve this objective a series of photophysical and photochemical studies will be done on the new compounds. These studies will be focused mainly on compounds which have modified phthalocyanine rings, since it is anticipated that the intrinsic photosensitizing capability of the phthalocyanine chromophore in them will vary in important ways from compound to compound.