CORE--DATA COLLECTION, MANAGEMENT, AND ANALYSIS

数据收集、管理和分析核心（数据核心）有两个主要目标：1）启动和维护不孕症队列，2）为项目研究者提供技术专业知识和支持。不孕症队列将包括620对夫妇，他们将在海湾地区选定的不孕症诊所进行初步咨询。队列成员将在任何ART尝试之前、初次ART尝试之后以及6个月、12个月和18个月随访时接受访谈。数据核心与启动和维护不孕症队列相关的职责包括受试者招募、入组和跟踪;培训访谈员和病历摘要员;安排和进行受试者访谈;进行病历审查以及创建克隆和编辑的数据库。数据中心还将以仪器开发和测试、数据收集以及一级和二级数据分析的形式为项目调查人员提供技术专长和支持。该计划项目中的三个项目将使用不孕症队列作为其主要数据来源;所有四个拟议项目都有概念联系，需要重叠的数据相关咨询资源，所有项目都有重叠的技术专长和支持需求。将资源集中到一个中央单位将丰富拟议的研究，使项目能够获得更广泛的人力和其他资源，并建立一个基础设施，使合作努力达到最大限度。数据核心将由一名主任、作为专业人员的主要研究者和共享研究人员组成。专业工作人员在确保项目成功所需的领域表现出专业知识，包括相关的科学领域，与跨学科团队进行合作研究，计划项目和中心赠款的经验，与不孕不育提供者和工作人员成功合作的历史，以及不孕不育患者的访问，以及模范领导经验。

The Core for Data Collection, Management, and Analysis (Data Core) has two primary objectives: 1) to initiate and maintain the Infertility Cohort, and 2) to provide technical expertise and support to project investigators. The Infertility Cohort will include 620 couples who are seen for an initial consultation visit at selected infertility practices in the Bay Area. Cohort Members will be interviewed prior to any ART attempts, following the initial ART attempt, and at 6, 12, and 18 month follow-ups. Responsibilities of the Data Core related to initiating and maintain the Infertility Cohort include subject recruitment, enrollment and tracking; training of interviewers and medical record abstractors; scheduling and conducting subject interviews; conducting medical record reviews and creation of a cloned and edited database. The Data ore will also provide technical expertise and support to project investigators in the form of instrument development and testing, data collection, and analysis of primary and secondary data. Three of the projects included in the program project will use the Infertility Cohort as its primary data source; all four of the proposed projects have conceptual linkages requiring overlapping data-related consultative resources, and all of the projects have overlapping technical expertise and support needs. Pooling resources into a central unit will enrich the proposed research by allowing projects access to a greater range of human and other resources, and by creating an infrastructure that will allow for maximum collaborative effort. The Data Core will be staffed by a Director, principal investigators who serve as professional personnel, and shared research personnel. Professional staff have demonstrated expertise in the areas necessary to ensure project success, including the scientific areas of relevance, the conduct of collaborative research with interdisciplinary teams, experience with program projects and center grants, a history of successful collaboration with infertility providers and staff and access to infertile patients, and exemplary leadership experience.