HUMAN PROLACTIN SECRETION IN VARIOUS ENDOCRINE DISORDERS

催乳素水平是在动态刺激期间测定垂体腺功能障碍患者的。重点是分泌性催乳素的垂体腺瘤患者，手术前后的情况。高催乳素血症和垂体功能低下的患者也在根据这一方案进行研究。后一组的动态研究可能有助于确定这些患者的垂体功能低下的机制。1986年发表的数据记载了催乳素动态研究在预测经蝶手术治疗催乳素分泌的垂体腺瘤患者的长期益处方面的有效性。功能性或非功能性腺瘤合并垂体功能减退的患者，催乳素水平通常升高。我们的研究表明，在这些情况下，催乳素水平升高的程度与减压手术后垂体功能恢复的可能性相关。我们正在比较和对比催乳素分泌动力学方面的数据，这些数据是通过评估同一患者的催乳素分泌的脉动性获得的。对10至25年前接受手术切除垂体腺瘤的患者的长期随访正在评估中。我们有一个主要的优势，跟踪了相对大量的这些患者，使我们能够进行这些长期研究。

Prolactin levels are determined in patients with pituitary dysfunction during dynamic provocative stimulation. The emphasis is on patients with prolactin secreting pituitary adenomas, pre and post surgical adenomectomy. Patients with hyperprolactinemia and hypopituitarism are also being studied under this protocol. The dynamic studies in the latter group is likely to help define the mechanism of hypopituitarism in these patients. The data documenting the usefulness of prolactin dynamic studies in predicting the long term benefit from transsphenoidal surgery in patients with prolactin secreting pituitary adenomas were published in 1986. Prolactin levels are often elevated in patients with functioning or non functioning adenomas associated with hypopituitarism. Our study has demonstrated that the degree of prolactin level elevation under these situations, correlate with the potential for recovery of pituitary function after decompressive surgery. We are in the process of comparing and contrasting data on the dynamics of prolactin secretion with that obtained from evaluating the pulsatile aspect of prolactin secretion in the same patients. The long term follow up of patients who had surgical resection of pituitary adenomas 10 to 25 years ago, is being assessed. We have a major advantage in following a relatively large number of these patients to allow us to do these long-term studies.