课题基金 / 基金详情

INTRACELLULAR HOMOCYSTEINE & METHIONINE KINETICS IN HUMANS

INTRACELLULAR HOMOCYSTEINE & METHIONINE KINETICS IN HUMANS
细胞内同型半胱氨酸
批准号：
6306068
负责人：
Dwight E Matthews
金额：
$3.29万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-02-28
来源：
https://reporter.nih.gov/project-details/6306068
关键词：
aminoacid metabolism bioimaging /biomedical imaging blood chemistry clinical research cystine diagnosis design /evaluation disulfide bond gas chromatography mass spectrometry homocysteine human subject hydrazines intracellular methionine method development pharmacokinetics reducing agents stable isotope diagnosis thiols

项目摘要

项目成果

Dwight E Matthews的其他基金

相关文献

中文摘要
翻译
同型半胱氨酸已被确定为心血管疾病的独立危险因素，但一些人血浆同型半胱氨酸浓度升高的原因尚不完全清楚。同型半胱氨酸是一种含硫氨基酸，是其他含硫氨基酸、甲硫氨酸和半胱氨酸之间的代谢中间体。Storch等人开发了一种使用稳定同位素示踪剂评价含硫氨基酸动力学的方法。
英文摘要
Homocysteine has been established as an independent risk factor in cardiovascular disease, but the reason why some individuals have elevated plasma homocysteine concentrations is not thoroughly understood. Homocysteine is a sulfur containing amino acid that is a metabolic intermediate between the other sulfur containing amino acids,methionine and cysteine. Storch et al. developed a method using stable isotope tracers to evaluate sulfur amino acid kinetics.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Mass Spectometry and Proteomics
A nano ESI-LCMS/MS Waters XEVO G2-S QTOF for UVM
VERMONT IMMUNOBIOL / INFECTIOUS DISEASES CTR: CORE C: PROTEOMICS ANALYSIS
VERMONT IMMUNOBIOL / INFECTIOUS DISEASES CTR: CORE C: PROTEOMICS ANALYSIS